نتایج جستجو برای: pca diagnosis

تعداد نتایج: 489498  

Journal: :Cancer letters 2008
Ramesh Ummanni Heike Junker Uwe Zimmermann Simone Venz Steffen Teller Jürgen Giebel Christian Scharf Christian Woenckhaus Frank Dombrowski Reinhard Walther

Prostate cancer (PCA) is the most common type of cancer found in men of western countries and is the leading cancer death next to lung cancer and colorectal cancer. Prostate-specific antigen (PSA) test is an established diagnostic tool for PCA detection, but confirmation of diagnosis by histopathological evaluation of prostate needle biopsies is performed. To define protein expression pattern o...

Journal: :PLoS ONE 2009
Raymond A. Clarke Zhongming Zhao An-Yuan Guo Kathrein Roper Linda Teng Zhi-Ming Fang Hema Samaratunga Martin F. Lavin Robert A. Gardiner

BACKGROUND The prostate cancer antigen 3 (PCA3/DD3) gene is a highly specific biomarker upregulated in prostate cancer (PCa). In order to understand the importance of PCA3 in PCa we investigated the organization and evolution of the PCA3 gene locus. METHODS/PRINCIPAL FINDINGS We have employed cDNA synthesis, RTPCR and DNA sequencing to identify 4 new transcription start sites, 4 polyadenylati...

Journal: :Scientific reports 2016
Jia Li Shancheng Ren Hai-Long Piao Fubo Wang Peiyuan Yin Chuanliang Xu Xin Lu Guozhu Ye Yaping Shao Min Yan Xinjie Zhao Yinghao Sun Guowang Xu

In-depth delineation of lipid metabolism in prostate cancer (PCa) is significant to open new insights into prostate tumorigenesis and progression, and provide potential biomarkers with greater accuracy for improved diagnosis. Here, we performed lipidomics and transcriptomics in paired prostate cancer tumor (PCT) and adjacent nontumor (ANT) tissues, followed by external validation of biomarker c...

Journal: :Cancer research 2002
Bao-Ling Adam Yinsheng Qu John W Davis Michael D Ward Mary Ann Clements Lisa H Cazares O John Semmes Paul F Schellhammer Yutaka Yasui Ziding Feng George L Wright

The prostate-specific antigen test has been a major factor in increasing awareness and better patient management of prostate cancer (PCA), but its lack of specificity limits its use in diagnosis and makes for poor early detection of PCA. The objective of our studies is to identify better biomarkers for early detection of PCA using protein profiling technologies that can simultaneously resolve a...

2013
Thomas Van den Broeck Lorenzo Tosco Stefan Prekovic Steven Joniau

The authors of the manuscript entitled " Obesity, diabetes and aggressive prostate cancer hormone– naïve at initial diagnosis [1] published in this issue performed a retrospective analysis of 266 patients who underwent prostate biopsies for suspected pros-tate cancer (PCa). Their results suggest that obesity and diabetes mellitus type II (DMII) are associated with more aggressive PCa (defined a...

2018
Tyler M Seibert Chun Chieh Fan Yunpeng Wang Verena Zuber Roshan Karunamuni J Kellogg Parsons Rosalind A Eeles Douglas F Easton ZSofia Kote-Jarai Ali Amin Al Olama Sara Benlloch Garcia Kenneth Muir Henrik Grönberg Fredrik Wiklund Markus Aly Johanna Schleutker Csilla Sipeky Teuvo LJ Tammela Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg M Andreas Røder Peter Iversen Tim J Key Ruth C Travis David E Neal Jenny L Donovan Freddie C Hamdy Paul Pharoah Nora Pashayan Kay-Tee Khaw Christiane Maier Walther Vogel Manuel Luedeke Kathleen Herkommer Adam S Kibel Cezary Cybulski Dominika Wokolorczyk Wojciech Kluzniak Lisa Cannon-Albright Hermann Brenner Katarina Cuk Kai-Uwe Saum Jong Y Park Thomas A Sellers Chavdar Slavov Radka Kaneva Vanio Mitev Jyotsna Batra Judith A Clements Amanda Spurdle Manuel R Teixeira Paula Paulo Sofia Maia Hardev Pandha Agnieszka Michael Andrzej Kierzek David S Karow Ian G Mills Ole A Andreassen Anders M Dale

OBJECTIVES To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age. DESIGN Analysis of genotype, PCa status, and age to select single nucleotide polymorphisms (SNPs) associated with diagnosis. These polymorphisms were incorporated into a survival analysis to estimate their effects on age at diag...

Journal: :International Journal of Aerospace Engineering 2023

The measurement of the pressure in gas generator (GG) plays a decisive role closed-loop regulation flow solid ducted rocket ramjet (SDR). Therefore, fault detection and isolation (FDI) sensors is particularly significant. Especially GG with double feedback, there are issues such as less available data sensor transmission, which make FDI more difficult. In this paper, for firstly, “Consistency I...

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