OBJECTIVE Endothelial dysfunction (ED) is a condition that involves increased oxidative stress and decreased total antioxidant status (TAS) levels. Systemic lupus erythematosus (SLE) is also associated with ED. We aimed to determine the association between serum TAS and ED as assessed by flow-mediated dilation (FMD) in patients with SLE. METHODS Thirty-four patients with stable SLE who were n...

Background: In previous studies, we reported that green tea decoction (GTD) cooked in boiling water for 15-min (15-min GTD) reduced body weight gain (BWG), glucose and lipid absorption and improved total antioxidant status (TAS) of rats fed normal or high-fat diet (HFD). However, the long-term effect of a mixture: 15-min GTD + lemon juice (LJ) on BWG, liver steatosis (LS), TAS, blood glucose an...

The molecular chaperone HSP90 plays a crucial role in cancer cell growth and survival by stabilizing cancer-related proteins. A number of HSP90 inhibitors have been developed clinically for cancer therapy; however, potential off-target and/or HSP90-related toxicities have proved problematic. The 4-(1H-pyrazolo[3,4-b]pyridine-1-yl)benzamide TAS-116 is a selective inhibitor of cytosolic HSP90α an...

Purpose: Investigators are currently conducting phase II trials on TAS-108, a novel oral steroidal antiestrogenic agent. The purpose of this study is to investigate the molecular and pharmacologic properties of TAS-108 compared with other antiestrogenic agents such as tamoxifen, raloxifene, and fulvestrant. Experimental Design: The antagonistic or agonistic activities of these agents against bo...

BACKGROUND Oxidative stress appears to have a central role in the pathophysiological process of uremia and its complications, including cardiovascular disease. However, there is little evidence to suggest how early oxidative stress starts developing during the progression of chronic kidney disease (CKD). The aim of this study is to assess oxidative stress activity in a cross-sectional study of ...

Examining the effect of imperfect transmit antenna selection (TAS) caused by the feedback link errors on the performance of hybrid TAS/space-time block coding (STBC) with selection combining (SC) (i.e., joint transmit and receive antenna selection (TRAS)/STBC) and TAS/STBC (with receive maximal-ratio combining (MRC)-like combining structure) over Nakagami-m fading channels is the main objective...

This paper deals with the problem of optimal decentralized power control in systems whose spectrum is regulated in time and space, the so-called time-area-spectrum (TAS) licensed. This license system gives to the owner the right of using a given frequency band at a given time and within a given geographical area. In this paper we consider those locations with colliding transmissions; thus, addr...

We analyzed the treatment responses, toxicities, and survival outcomes of patients with relapsed or refractory multiple myeloma who received daily thalidomide, cyclophosphamide, and dexamethasone (CTD) or daily thalidomide, melphalan, and prednisolone (MTP) at 17 medical centers in Korea. Three-hundred and seventy-six patients were enrolled. The combined chemotherapy of thalidomide, corticoster...

Introduction The sources of Reactive Oxidative Species (ROS) in the organism are the respiratory processes occurring in cells catalyzed by different enzymes. Operation of ROS is balanced by antioxidants, the compounds; although present in low concentrations, they significantly inhibit the degree of oxidation of particular molecules. The Aim of the Study The aim of this study was to assess the...

In this paper we study the relation between the two main extensions of Answer Set Programming with temporal modal operators: Temporal Equilibrium Logic (TEL) and Temporal Answer Sets (TAS). On the one hand, TEL is a complete non-monotonic logic that results from the combination of Linear-time Temporal Logic (LTL) with Equilibrium Logic. On the other hand, TAS is based on a richer modal approach...