Patient-derived xenograft (PDX) models have shown to reflect original patient tumors better than any other preclinical model. We embarked in a study establishing a large panel of head and neck squamous cell carcinomas PDX for biomarker analysis and evaluation of established and novel compounds. Out of 115 transplanted specimens 52 models were established of which 29 were characterized for respo...

COX-2 expression level and prognostic value are still a matter of debate in breast cancer (BC). We addressed these points in the context of PIK3CA mutational status. Based on an interesting study of aspirin efficacy in colorectal cancer, we hypothesized that celecoxib antitumoral activity may be restricted to PIK3CA mutated BC.COX-2 mRNA expression was analyzed in 446 BC samples and in 61 BC pa...

furin is a ca 2+ -dependent serine protease which cleaves proprotein substrates at the arg-xaa-(lys/arg)-arg    site to generate biologically active proteins. furin’s critical role in many cellular events associated with health disorders such as hiv, sars, anthrax, and influenza as well as cancer has made inhibitors of this enzyme as therapeutic targets. to this date, the most potent inhibitor ...

BACKGROUND Gut microbiota is now known to control glucose metabolism. Previous studies have shown that probiotics and prebiotics may improve glucose metabolism, but their effects have not been studied in combination with drug therapy. The aim of this study was to investigate whether probiotics and prebiotics combined with drug therapy affect diabetic outcomes. METHODS Two different study desi...

Advanced cutaneous squamous cell carcinoma (cSCC) can be managed with chemotherapy/radiotherapy, but often unsatisfactory clinical outcomes. Currently, no preclinical research has been performed to evaluate the efficacy of eribulin against cSCC. In this study, we investigate administration using cSCC lines and a novel patient-derived xenograft (PDX) model. (A431 DJM-1), was proven suppress tumo...

In this paper, we consider the existence of positive solutions to the following p Kirchhoff-type system ⎧⎪⎨⎪⎪⎩ −M (∫ Ω |∇u|pdx ) Δpu = g(x)|u|q−2u+ α α+β |u|α−2u|v|β , x ∈Ω, −M (∫ Ω |∇u|pdx ) Δpv = h(x)|v|q−2v+ β α+β |u|α |v|β−2v, x ∈Ω, u = v = 0, x ∈ ∂Ω, where Ω is a bounded domain in RN , M(s) = a + bsk , Δpu = div(|∇u|p−2∇u) is the p Laplacian operator, α > 1 , β > 1 , 1 < p < q < α +β < p∗ ...

Objective: The aim of this study was to investigate the effect of 12 weeks aerobic training on PDX-1 and GLUT2 gene expression in the pancreatic tissue of type 2 diabetic rats. Materials and Methods: 21 wistar male rats were placed in 3 groups (healthy, diabetic, aerobic diabetic). Diabetes was induced by peritoneum injection of nicotine amid. Training program lasted 12 weeks, five sessions pe...

We study the large time behavior of solutions of the PDE |vt |p−2vt = pv. A special property of this equation is that the Rayleigh quotient ∫ |Dv(x, t)|pdx/ ∫ |v(x, t)|pdx is nonincreasing in time along solutions. As t tends to infinity, this ratio converges to the optimal constant in Poincaré’s inequality. Moreover, appropriately scaled solutions converge to a function for which equality holds...