Large well-designed clinical efficacy and safety randomized clinical trials (RCTs) are required to achieve regulatory approval of new drug treatments. The objective of this article is to make recommendations for the criteria for defining and selecting the clinical trial study population, design and efficacy outcomes measures which comprise ideal premature ejaculation (PE) interventional trial m...

OBJECTIVE To expand the search for preeclampsia (PE) metabolomics biomarkers through the analysis of acylcarnitines in first-trimester maternal serum. METHODS This was a nested case-control study using serum from pregnant women, drawn between 8 and 14 weeks of gestational age. Metabolites were measured using an UPLC-MS/MS based method. Concentrations were compared between controls (n = 500) a...

INTRODUCTION Human papillomavirus (HPV) has been consistently implicated in causing several kinds of malignancies, and two HPV oncogenes, E6 and E7, represent two potential target antigens for cancer vaccines. We developed two fusion protein vaccines, PE(ΔIII)/E6 and PE(ΔIII)/E7 by targeting these two tumor antigens to test whether a combination of two fusion proteins can generate more potent a...

the incorporation of several anti-rodent masterbatches into polyethylene (pe) granules used for gas pipes and the effects of the masterbatches on the physical properties of the pipes were studied. four commercial anti-rodent masterbatches from different international companies including, clariant, alchemix, polyone, and newgen were used in this research. each of the masterbatch was primarily dr...

conclusions: pe may be developed as late as weeks after cardiac surgeries. pe after palliative cardiac surgeries is not uncommon. low doses of aspirin and corticosteroids are usually effective for treating this complication. objectives: our aim was to assess the prevalence, risk factors, time course and therapy response of pericardial effusion (pe) after cardiac surgeries in children. patients ...

background: lack of sufficient information on the mechanism of plasma exchange (pe) therapy in multiple sclerosis (ms), has limited this treatment to individual patients with severe relapses who have been refractory to other treatments. this is while pe is used very successfully as a first-line standard treatment in many other neuro-immune disorders. recent data suggest that treg/th17 counterba...

Extracellular plaques of amyloid-b and intraneuronal neurofibrillary tangles made from tau are the histopathological signatures of Alzheimer’sdisease.Plaques comprise amyloid-b fibrils that assemble from monomeric and oligomeric intermediates, and are prognostic indicators of Alzheimer’s disease. Despite the importance of plaques to Alzheimer’s disease, oligomers are considered to be the princi...

This study investigated the role of dissolved organic matter on mercury partitioning between a hydrophobic surface (polyethylene, PE) and a reduced sulfur-rich surface (polysulfide rubber, PSR). Comparative sorption studies employed polyethylene and polyethylene coated with PSR for reactions with DOM-bound mercuric ions. These studies revealed that PSR enhanced the Hg-DOM removal from water whe...

the effects of three  anesthetics, clove oil (co) ( 30 mgl-1), 2-phenoxy ethanol (2-pe) (0.3 mll-1), and ms-222 (100 mgl-1) were examined on blood enzymes including lactate dehydrogenase (ldh), creatine kinase (ck), alanine aminotransferase (alt), aspartate aminotransferase (ast), albumin, glucose, and cortisol levels in the caspian brown trout. blood parameters were evaluated in the control (n...

BACKGROUND Preeclampsia (PE) is a pregnancy-related vascular disorder which is the leading cause of maternal morbidity and mortality. We sought to identify novel serological protein markers to diagnose PE with a multi-'omics' based discovery approach. METHODS Seven previous placental expression studies were combined for a multiplex analysis, and in parallel, two-dimensional gel electrophoresi...