Motivation Site directed mutagenesis is widely used to understand the structure and function of biomolecules. Computational prediction of mutation impacts on protein stability offers a fast, economical and potentially accurate alternative to laboratory mutagenesis. Most existing methods rely on geometric descriptions, this work introduces a topology based approach to provide an entirely new rep...

We describe a system that combines guided navigation with the computation of Pearson correlation coefficients to support the task of interactive data mining by creating dynamic previews of possible navigation states. Author

In statistics, the Pearson correlation coefficient rx,y determines the degree of linear correlation between two variables and it is known that −1 ≤ rx,y ≤ 1. In the theory of networks, a curious expression proposed in [PRL 89 208701 (2002)] for degree-degree correlation coefficient rji,ki , i ∈ [1,M ] has been in use. We realize that the suggested form is the conventional Pearson’s coefficient ...

It is widely appreciated that many studies in psychological science suffer from low statistical power. One of the consequences analyzing underpowered with thresholds significance a high risk finding exaggerated effect size estimates, right or wrong direction. These inferential risks can be directly quantified terms Type M (magnitude) error and S (sign) error, which communicate design choices on...

BACKGROUND In times of globalization there is an increasing use of English in the medical literature. The aim of this study was to analyze the influence of English-language articles in multi-language medical journals on their international recognition--as measured by a lower rate of self-citations and higher impact factor (IF). METHODS AND FINDINGS We analyzed publications in multi-language j...

BACKGROUND Structural remodeling is associated with the fibroinflammatory process in the atrial extracellular matrix. In the present study we aimed to investigate whether serum levels of new circulating remodeling markers differ in patients with atrial fibrillation (AF) compared to patients with sinus rhythm. MATERIAL AND METHODS The study population included 52 patients diagnosed with non-va...

BACKGROUND Despite the importance of hamstring tendon autograft, one major disadvantage in applying this technique in the surgical reconstruction of anterior cruciate ligament is individual variability in the tendon diameter. Hence, the purpose of the present study was to use anthropometric parameters such as gender, height and body mass index to predict 4-strand (quadruple) hamstring tendons (...

Description The Function performs a parallel analysis using simulated polychoric correlation matrices. The nth-percentile of the eigenvalues distribution obtained from both the randomly generated and the real data polychoric correlation matrices is returned. A plot comparing the two types of eigenvalues (real and simulated) will help determine the number of real eigenvalues that outperform rand...