BACKGROUND Pelvic organ prolapse is common, and some degree of prolapse is seen in 50% of parous women. Women with prolapse can experience a variety of pelvic floor symptoms. Treatments include surgery, mechanical devices and conservative management. Conservative management approaches, such as giving lifestyle advice and delivering pelvic floor muscle training, are often used in cases of mild t...

It was hypothesized that the processes contributing to pelvic organ prolapse (POP) may be identified by transcriptional profiling of pelvic connective tissue in conjunction with light microscopy. In order to test this, we performed a frequency-matched case-control study of women undergoing hysterectomy for POP and controls. Total RNA, extracted from uterosacral and round ligament samples used t...

OBJECTIVE The objective of the study was to determine the incidence of ureteral obstruction during vaginal surgery for pelvic organ prolapse and the accuracy and efficacy of intraoperative cystoscopy. STUDY DESIGN The study was a retrospective review of 700 consecutive patients who underwent vaginal surgery for anterior and/or apical pelvic organ prolapse with universal intraoperative cystosc...

This article is a comprehensive review of the pelvic cosmetic procedure, vaginal rejuvenation. The review covers the inception, evolution, and challenges involved with the operation. Comparison with the classic procedures from which it was derived as well as similar current procedures designed for pelvic organ prolapse are covered. Indications, patient selection, expected outcomes, and technica...

OBJECTIVES The LOXL1 (lysyl oxidase-like 1) gene encodes a copper-dependent monoamine oxidase that catalyzes the deamination of a lysine residue in the cross-linking of tropoelastin monomers to form elastin. LOXL1-KO mice do not deposit normal elastic fibers in their genitourinary tract resulting in postpartum pelvic organ prolapse and lower urinary tract dysfunction with decreased bladder capa...

OBJECTIVE To compare the frequency of asymptomatic microhematuria (AMH) in patients with stage 2-4 and stage 0-1 pelvic organ prolapse (POP). METHODS The hospital database was searched for women diagnosed with pelvic floor disorders and all medical records were reviewed retrospectively for the presence of AMH. An additional search was conducted for women with other benign gynecological condit...

Matrix metalloprotease (MMP) activity is increased in the postpartum vagina of wild-type (WT) animals. This degradative activity is also accompanied by a burst in elastic fiber synthesis and assembly. The mechanisms that precipitate these changes are unclear. The goals of this study were to determine how vaginal distention (such as in parturition) affects elastic fiber homeostasis in the vagina...

The long term durability of conventional surgical repair of vaginal prolapse has been questioned in recent years. In a frequently quoted publication Olsen et al.1 estimated that the lifetime risk (up to age 80 years) of undergoing surgery for vaginal prolapse was 11%. Between 29% and 40% of prolapse surgery is for recurrence 1, 2 and in 60% of re-operations the prolapse is at the site of the or...

Background and aims: Pelvic organ prolapse (POP) is a common disease which is presented as symptomatic descent of the anterior, posterior vaginal wall or apical prolapse. Since, social and cultural factors have impact on interval between symptoms incidence and seek for medical care, diagnosis method and treatment process, it was important to prepare a guideline for management of the Iranian wom...

OBJECTIVE To provide an update on transvaginal mesh procedures, newly available minimally invasive surgical techniques for pelvic floor repair. OPTIONS The discussion is limited to minimally invasive transvaginal mesh procedures. EVIDENCE PubMed and Medline were searched for articles published in English, using the key words "pelvic organ prolapse," transvaginal mesh," and "minimally invasi...