OBJECTIVE Autoimmune bullous diseases are heterogeneous diseases and the differentiation between the various bullous disease is important for treatment and prognosis. Direct immunofluorescence microscopy is still the gold standard in differentiating these diseases. Our aim was to determine the diagnostic accordance between clinical and histopathological/direct immunofluorescence diagnosis of pa...

OBJECTIVES To conduct a cross-sectional study to compare Dsg1 and Dsg3 antibody levels independently with severity of disease activity in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). METHODS Blood samples from 44 patients with pemphigus (PV-38, PF-6) were analyzed using ELISA. The severity of skin and mucosal disease was graded using a score from 0 to 3. RESULTS A statistically sig...

BACKGROUND AND AIMS Pemphigus is a chronic autoimmune and vesiculobollous disease that can affect skin and different mucous membrane surfaces. Primary manifestations occur in oral cavity in almost 60% of cases. The purpose of the present study was to evaluate the epidemiology of pemphigus in Tehran, Iran in a 20-year period. MATERIALS AND METHODS A retrospective study was conducted on the rec...

INTRODUCTION Involvement of upper gastrointestinal tract in pemphigus vulgaris is not uncommon. AIM To study the involvement of upper gastrointestinal tract (UGIT) with the help of esophago-gastro-duodenoscopy (EGD) in patients of vesiculobullous dermatoses with emphasis on pemphigus vulgaris. METHODS Forty-two patients (M-22, F-20) with vesiculobullous dermatoses, diagnosed on the basis of...

BACKGROUND The occurrence in the same patient of three or more autoimmune diseases defines multiple autoimmune syndrome (MAS). Various autoimmune dermatoses, especially pemphigus, have been described in association with systemic autoimmune diseases as component of MAS. AIM The aim of our study is to describe MAS with a new combination in a 55-year-old woman having a pemphigus vulgaris, associ...

diseases and is divided into two vulgaris and foliaceus pemphigus and mainly appears during fifties and sixties.1,2 Its etiology is not exactly known and genetic talent may play a role in its development.3,4 The disease is globally widespread and is more common in some races.5,6 A study was conducted to evaluate the HLA-class I in patients suffering from pemphigus. Patients with skin biopsy of ...

Dermatol 2006;142:570–6. 21 Beissert S, Werfel T, Frieling U et al. A comparison of oral methylprednisolone plus azathioprine or mycophenolate mofetil for the treatment of pemphigus. Arch Dermatol 2006;142:1447–54. 22 Ahmed AR, Spigelman Z, Cavacini LA, Posner MR. Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin. N Engl J Med 2006;355:1772–9. 23 Joly P, Mouquet H, ...