Background& Aims: Gastric adenocarcinoma has been considered as an infectious disease since 1994, when the Helicobacter pylori (H. pylori) infection categorized as a definite class I human carcinogen. H. pylori uses extensive numbers of virulence factors to overcome host defence mechanisms. One independent H. pylori factor that plays an important role in determining H.pylori pathogenesisis vacu...

BACKGROUND Although Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs) are the main causes of peptic ulcers disease (PUD), recently the prevalence of idiopathic peptic ulcer (IPU) is increasing in most parts of the world. The aim of this study was to assess the prevalence of IPU in Kerman, the center of largest province in south-east Iran. METHODS We included 215 patients wi...

OBJECTIVES Patients with peptic ulceration continue to present to surgeons with complications of bleeding or perforation and to die under surgical care. This study sought to examine whether improved consultant input, timely interventions and perioperative care could reduce mortality from peptic ulcer. DESIGN Prospective collection of peer-review mortality data using Scottish Audit of Surgical...

BACKGROUND Diagnoses of peptic ulcer are registered in the Danish National Patient Registry (DNPR) for administrative as well as research purposes, but it is unknown whether the coding validity depends on the location of the ulcer. OBJECTIVE To validate the International Classification of Diseases, 10th revision diagnosis codes of peptic ulcer in the DNPR by estimating positive predictive val...

Peptic ulcer is a Common diseuse with potentially serious complications. Perforation of the one such complication that can be fatal if left untreated. We present rare case kissing peptic ulcers in 42-year-old patient who presented hematemesis and melena was admitted to intensive care unit hemorrhagic shock post trauma. Despite failed endoscopic hemostasis measures, successfully treated surgical...

The treatment of peptic ulcer is an ever increasing problem to the internist and surgeon alike. Those who attempt to treat the ulcer patient consrientiously are daily confused by the multiplicity of articles and conflicting results found in the literature today. There are many advocates of a strict antacid and dietary regimen and almost as many others claim that antacids and diet are valueless....

Vagus nerve may play a role in serum glucose modulation. The complicated peptic ulcer patients (with perforation or/and bleeding) who received surgical procedures with or without vagotomy provided 2 patient populations for studying the impact of vagus nerve integrity. We assessed the risk of developing type 2 diabetes in peptic ulcer patients without and with complications by surgical treatment...

BACKGROUND It is presently not well understood to what extent peptic ulcer and gastric cancer represent related diseases. AIMS The objective of this study was to assess past occurrence of gastric and duodenal ulcers in patients with cancer of the gastric cardia or other parts of the stomach. METHODS The association between peptic ulcer and gastric cancer was studied among patients followed ...

BACKGROUND/AIMS The connection between Helicobacter pylori and complicated peptic ulcer disease in peptic ulcer bleeding (PUB) patients taking nonsteroidal anti-inflammatory drugs has not been established. In this study, we sought to determine whether delayed H. pylori eradication therapy in PUB patients increases complicated recurrent peptic ulcers. METHODS We identified inpatient PUB patien...

We performed an electronic search in Medline and EMBASE for papers comparing Helicobacter pylori eradication and H(2)RA-maintenance therapy in peptic ulcer. Treatment to eradicate H. pylori in patients with a proven ulcer has a favorable cost-effectiveness compared with maintenance therapy, with benefits for the patient and society. In most studies, it was assumed that no more gastrointestinal ...