AIMS Reliance on intraocular pressure, optic nerve cupping changes, nerve fibre layer integrity, and visual field changes may delay treatment of glaucoma since irreversible changes may have already occurred at the time of diagnosis. Abnormal pattern electrical retinal responses (PERR or PERG) have been demonstrated in patients with ocular hypertension (no visual field changes) and glaucoma when...

96 Subcutaneous apomorphine in the treatment of Parkinson's disease J P Frankel, A J Lees, P A Kempster, G M Stern 102 Nasogastric and intravenous infusions of ( + )-4-propyl-9-hydroxynaphthoxazine (PHNO) in Parkinson's disease R J Coleman,NP Quinn,M Traub, C D Marsden 106 Syringomyelia and arachnoiditis L R Caplan, A B Norohna, L L Amico 114 Simultaneous VEP and PERG investigations in early Pa...

AIM To characterise the phenotype of an autosomal dominant cone-rod dystrophy (CORD7) associated with the Arg844His mutation in RIM1. METHODS Eight members of a four generation, non-consanguineous British family were examined clinically and underwent electrophysiological testing, automated dark adapted perimetry, dark adaptometry, colour vision assessment, colour fundus photography, fundus fl...

Electroretinography is a mainstay of clinical ophthalmic diagnostic testing. The electroretinogram, or ERG, provides an objective, quantitative measure of retinal function and allows the clinician to monitor the function of rod cells, cone cells, and ganglion cells in each eye. It uses electrodes placed on the cornea or adjacent to the orbit to monitor changes in the electrical potential of the...

Aims: To characterise patients with birdshot chorioretinopathy (BCR) clinically and electrophysiologically in order to monitor changes in retinal function before and after treatment with corticosteroids and/or immunosuppression. Methods: 18 patients with BCR were characterised clinically and electrophysiologically. Serial studies were performed on 14 patients in order to monitor changes in reti...

Forced infestation studieswere conducted to determinewhether northern or southern highbush blueberries, Vaccinium corymbosum L., are hosts for the invasive tephritid fruit ßies in Hawaii. Fruit were exposed to gravid female ßies of Bactrocera dorsalis Hendel (oriental fruit ßy), Ceratitis capitata (Wiedemann) (Mediterranean fruit ßy), or Bactrocera cucurbitae Coquillet (melon ßy) in screen cage...

AIMS To characterise patients with birdshot chorioretinopathy (BCR) clinically and electrophysiologically in order to monitor changes in retinal function before and after treatment with corticosteroids and/or immunosuppression. METHODS 18 patients with BCR were characterised clinically and electrophysiologically. Serial studies were performed on 14 patients in order to monitor changes in reti...

Huntington's disease (HD) is an inherited neurodegenerative disorder that primarily affects the medium-size GABAergic neurons of striatum. The R6/2 mouse line is one of the most widely used animal models of HD. Previously the hallmarks of HD-related pathology have been detected in photoreceptors and interneurons of R6/2 mouse retina. Here we aimed to explore the survival of retinal ganglion cel...

PURPOSE To determine in patients with ocular hypertension (OHT) or early glaucoma (EOAG) the change in blood flow measured at the neuroretinal rim of the optic disc in response to a 15-Hz diffuse green luminance flicker, a stimulus that activates predominantly the ganglion cell magnocellular pathway. METHODS Thirteen patients with EOAG, 29 with OHT, and 16 age-matched control subjects, all wi...

the head for evaluation of memory loss. She received 100 ml of diatrizoate meglumine (Angiovist 282), an intravenous RCM. The patient had never previously been exposed to RCM and within 1 mm of its administration, she complained of severe dyspnea and a sensation of fullness in her neck, as if someone were choking her. The radiologist evaluating the patient did not report evidence of facial swel...