A female patient of 16 years of age reported with a chief complain of severe pain , swelling and pus discharge with respect to right lower back tooth region since two days,with a previous history of sensitivity to hot and cold. On the basis of case history ,clinical and radiographic findings case was diagnosed as primary endodontic lesion with secondary periodontal involvement,and was decided t...

The pulp and periodontium are intimately related owing to the various communications present between the two. So a disease in one can progress to the other posing difficulties in the management of such lesions. Proper diagnosis is essential in endodontic-periodontal lesions so that proper treatment can be prescribed. Treatment of combined endo-perio lesions is complex and proper sequence of man...

Objective: The purpose of this review literature is to look at the mechanism mesenchymal stem cell secretome in regeneration periodontal tissue.Methods: This was collected from several journals and research that has been done, where application Mesenchymal cells (MSCs) promises a favourable result for cell-based therapy inflammatory diseases, immune system disorders, regeneration, tissue repair...

Introduction: Periodontal regenerative therapy goals are to prevent and repair the soft hard tissue that has been damaged by infection. The membrane used as a material of periodontal therapy. Resorbable non-resorbable membranes were physical barriers avoiding growth connective epithelial into defect area. This review will be discussed about new development materials for Guided Tissue Regenerati...

The regeneration of periodontal tissues still remains a challenge in periodontology. The aim of the present study was to examine the regenerative potential of a) different collagen support versus blank, b) different collagen support +/- a growth factor cocktail (GF) and c) a collagen powder versus collagen powder + periodontal ligament stem cells (PDLSCs) comparatively in a large animal model. ...

This human clinical trial evaluated the clinical and histologic response to recombinant human platelet-derived growth factor-BB (rhPDGF-BB) delivered in bone allograft for the treatment of advanced Class II furcation defects. Three mandibular and one maxillary molar furcation defects were treated: Two received 0.5 mg/mL and two received 1.0 mg/mL rhPDGF-BB, in all cases mixed with DFDBA. Clinic...

BACKGROUND Matrix metalloproteinases (MMPs) degrade the extracellular matrix (ECM) and regulate remodeling and regeneration of bone. Enamel matrix derivative (EMD) protein has been used clinically for periodontal regeneration, although its molecular mechanisms are not clear. We evaluated the role of matrix metalloproteinases (MMPs) in regulating EMD-dependent degradation of gelatin on oeoblast-...

Background and aims. A combination of guided tissue regeneration (GTR), bovine porous bone mineral (BPBM), and platelet rich plasma has been already applied for the regeneration of intrabony defects. The aim of this study was to determine the role of plasma rich in growth factor (PRGF) alone in the periodontal regeneration of intrabony defects in humans as compared with BPBM/GTR Technique. Mate...

The amelogenins are secreted by the ameloblast cells of developing teeth; they constitute about 90% of the enamel matrix proteins and play an important role in enamel biomineralization. Recent evidence suggests that amelogenin may also be involved in the regeneration of the periodontal tissues and that different isoforms may have cell-signalling effects. During enamel development and mineraliza...

This article is limited to a review of bone replacement graft materials used in periodontal therapy. The source, mode of bone regeneration and the respective advantages and disadvantages of autogenous, allogenic, xenogenic and alloplastic materials are discussed.