PURPOSE To evaluate the reproducibility of the peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained by Spectralis spectral domain optical coherence tomography (OCT) (Heidelberg Engineering, Heidelberg, Germany) in normal and glaucoma participants. METHODS Participants were recruited from a university-based clinic. Peripapillary RNFL thickness measurements were repeat...

PURPOSE To evaluate the effect of two intravitreal bevacizumab (IVB) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with wet type age-related macular degeneration (ARMD). METHODS This prospective interventional case series included 18 eyes of 18 patients receiving two IVB injections within a 6 weeks interval for treatment of wet type ARMD. Peripapillary RNF...

PURPOSE To compare choroidal thickness (CT) between individuals with and without glaucomatous damage and to explore the association of peripapillary and submacular CT with glaucoma severity using spectral domain optical coherence tomography (SD-OCT). METHODS Ninety-one eyes of 20 normal subjects and 43 glaucoma patients from the UCLA SD-OCT Imaging Study were enrolled. Imaging was performed u...

PURPOSE The biomechanical effects of IOP on the optic nerve head (ONH) are believed to play a role in glaucomatous neuropathy. There is, however, no consensus on which effects of IOP should be prioritized for investigation. Our goal was to identify a small set of variables capturing the majority of the effects of acute IOP on the ONH. METHODS We produced 4646 finite element models of the huma...

Purpose To compare the sectoral structure-function relationships in glaucoma between two structural parameters, vessel density (VD) and thickness, in the peripapillary retinal nerve fiber layer (RNFL). Methods Optical coherence tomography (OCT) angiography (AngioVue/RTVue-XR) for VD and OCT (RS-3000) for peripapillary RNFL thickness were performed in 129 eyes from 129 subjects (94 glaucoma, 1...

Purpose To investigate the effects of intraocular pressure (IOP) reduction on the eyeball shape in highly myopic eyes with high IOP. Methods This study included patients with an axial length ≥26.5 mm and high IOP ≥22 mmHg after receiving maximum medication, with successful trabeculectomy by a single surgeon, and who underwent swept-source optical coherence tomography (SS-OCT) examinations on ...

PURPOSE This study examined the peripapillary choroidal thickness (PCT) in nonarteritic ischemic optic neuropathy (NAION) in comparison to contralateral eyes and normal eyes. METHODS We used enhanced depth imaging spectral-domain optical coherence tomography to image the optic nerve head of 20 NAION, 10 contralateral eyes, and 102 normal eyes. Following compensation, the scans were manually d...

PURPOSE To analyze the vasculature and extracellular matrix changes in the prelaminar region (PreLR) of the optic nerve head (ONH) and in the peripapillary sclera of eyes with primary open-angle glaucoma (POAG) and age-matched control eyes. METHODS In histologic sagittal sections of 46 eyes with POAG and 45 control eyes (donor ages, 20-96 years), the peripapillary sclera and penetrating vesse...

Examining the macula by means of segmentation with optic coherence tomography (OCT) has expanded our analytical capacity when compared with the conventional examination of the peripapillary retina nervous fiber layer (RNFL), to the extent that at present, in addition to evaluating macular axons (macular nervous fiber layer), we are able to evaluate the neuronal sub-populations comprising said l...

PURPOSE To investigate the peripapillary choroidal thickness (PCT) of polypoidal choroidal vasculopathy (PCV) and exudative age-related macular degeneration (AMD) and to evaluate their responses to anti-vascular endothelial growth factor (VEGF). METHODS Thirty eyes with PCV and 25 eyes with exudative AMD who were treatment naïve were included in this study. PCT and subfoveal choroidal thickne...