نتایج جستجو برای: peripheral mononuclear cell pbmc

تعداد نتایج: 1813954  

2017
Alessandro Bertolo David Pavlicek Armin Gemperli Martin Baur Tobias Pötzel Jivko Stoyanov

Immunomodulatory properties of mesenchymal stem cells (MSC) are key components of their successful applications in clinical setting. However, treatments based on MSC immunomodulation need understanding of cell characteristics before cell transplantation. We used live-imaging to test the suitability of the MSC motility as a parameter for quick prediction of the immunomodulatory potential of huma...

Objective(s): The primary cytotoxic effects of anticancer drugs like idarubicin, a chemotherapeutic agent, are not limited to neoplastic cells; they also produce similar effects in normal cells. In this study, we hypothesized that the combination of idarubicin-bromelain could make cancer cells more susceptible to cytotoxicity and genotoxicity.Material...

Journal: :علوم دامی ایران 0
هادی آتشی دانش آموخته گروه علوم دامی دانشگاه تهران و استادیار دانشگاه شیراز محمد مرادی شهربابک پردیس کشاورزی و منابع طبیعی دانشگاه تهران حسن مهربانی یگانه عضو هیات علمی گروه علوم دامی، دانشکده¬ی علوم دامی، پردیس کشاورزی و منابع طبیعی دانشگاه تهران سید رضا میرایی آشتیانی پردیس کشاورزی و منابع طبیعی دانشگاه تهران قدرت اله رحیمی میانجی دانشکده¬ی علوم دامی و شیلات، دانشگاه کشاورزی و منابع طبیعی ساری

potential relationships between amino acid motifs in the antigen binding groove of various alleles of the bovine major histocompatibility complex dr (bola-dr) molecule and peripheral blood mononuclear cell (pbmc) proliferation, in response to s. aureus and phytohemaglutinin, were investigated. the animals included in the study were approximately of the same age and comprised of pure holstein-fr...

Journal: :Cancer research 1985
E C Bradley J J Catino B F Issell B Poiesz J M Hustad T Dalton M Allegretta J Mier

Human nonadherent peripheral blood mononuclear cells (PBMC) isolated from nonimmunized donors were preincubated for 18 h in medium alone or medium containing the lymphokine interleukin 2 and subsequently cocultured with tumor cells derived from malignant tumor cell lines or from fresh human tumors. The cell suspensions were subsequently inoculated into agarose; 14 days later, new tumor colony f...

Journal: :Molecules 2014
Thiago A P de Moraes Maria J S Filha Celso A Camara Tania M S Silva Bruno M Soares Igor S Bomfim Claudia Pessoa George C Ximenes Valdemiro A Silva Junior

The cytotoxicity of a series of aminonaphthoquinones resulting from the reaction of suitable aminoacids with 1,4-naphthoquinone was assayed against SF-295 (glioblastoma), MDAMB-435 (breast), HCT-8 (colon), HCT-116 (colon), HL-60 (leukemia), OVCAR-8 (ovarian), NCI-H358M (bronchoalveolar lung carcinoma) and PC3-M (prostate) cancer cells and also against PBMC (peripheral blood mononuclear cells). ...

2016
Hongliang Wang Na Sun Ka Li Jiguang Tian Jianmin Li

BACKGROUND Ankylosing spondylitis (AS) involves inflammation at the sacroiliac joint and spine attachment site. This study aimed to observe the ratio and function of peripheral regulatory Vδ1 T cells in AS patients to investigate their roles in AS pathogenesis. MATERIAL AND METHODS Peripheral blood mononuclear cells (PBMC) were separated by density-gradient centrifugation from AS patients and h...

2017
Axel Fun Hoi Ping Mok Mark R. Wills Andrew M. Lever

Cure of Human Immunodeficiency Virus (HIV) infection remains elusive due to the persistence of HIV in a latent reservoir. Strategies to eradicate latent infection can only be evaluated with robust, sensitive and specific assays to quantitate reactivatable latent virus. We have taken the standard peripheral blood mononuclear cell (PBMC) based viral outgrowth methodology and from it created a log...

Journal: :Blood 1990
A Gessain F Saal O Gout M T Daniel G Flandrin G de The J Peries F Sigaux

Human T-cell lymphotropic virus type I (HTLV-I) proviral integration status was examined by Southern blot analysis in peripheral blood mononuclear cell (PBMC) DNA from patients presenting a tropical spastic paraparesis (TSP) and serological evidence of HTLV-I infection. Surface phenotype and morphological aspects of PBMC were also studied. A polyclonal HTLV-I proviral integration was found in t...

Journal: :The Journal of general virology 1999
S Z Shapiro T Maudru K W Peden

Application of a highly sensitive PCR-based reverse transcriptase (RT) assay to the analysis of the infection of CD4+ cell lines with human immunodeficiency virus type 1 (HIV-1) demonstrated that virus production can be detected as early as 24 h after infection. Most of the signal at 24 h was due to virus production, as it could be substantially reduced by prior treatment with the RT inhibitor ...

Journal: :Journal of leukocyte biology 1998
D Cooper N R Pellis

Utilizing clinostatic rotating wall vessel (RWV) bioreactors that simulate aspects of microgravity, we found phytohemagglutinin (PHA) responsiveness to be almost completely diminished. Activation marker expression was significantly reduced in RWV cultures. Furthermore, cytokine secretion profiles suggested that monocytes are not as adversely affected by simulated microgravity as T cells. Reduce...

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