background: effects of platelet-derived growth factor b (pdgf-b) on peripheral nerve regeneration was studied using a rat sciatic nerve transection model. materials and methods: forty‑five male, white wistar rats were divided into three experimental groups (n = 15), randomly: normal control group (nc), silicon group (sil), and pdgf‑b treated group (sil/pdgf). in nc group, left sciatic nerve was...

Peripheral nerve trauma impacts both social and occupational quality of life. Patients are typically young subsequently suffer from lifelong disability. Unlike the central nervous system, peripheral system has capacity to regenerate along previous or new connections. Yet, complete functional recovery been an elusive clinical objective despite development advanced microsurgical techniques repair...

In microsurgical nerve repair, the epineural sleeve technique can be used to bridge short nerve defects and to coverthe coaptation site with the epineurium of the nerve stump. The epineurium serves as a mechanical aid to reducegap size, and increase repair strength, effectively assisting nerve regeneration.This article presents a 32-year-old patient who experienced complete transection of the m...

Peripheral nerve injuries (PNIs) present a serious medical concern, constituting approximately 100,000 neurosurgical procedures in the US and Europe annually. Despite this large number, only 50% of patients achieve good to normal restoration of function following surgical repair. This is due to current insufficiencies with PNI repair strategies to treat major nerve trauma, defined as loss of a ...

Peripheral nerve defects, but not artificial nerves, are repaired by endogenous cells. We examined cell activity during the repair process in the presence of autologous nerves and artificial preparations in order to guide future artificial nerve fabrication. PLGA tubes, nerve scaffolds comprising a PLGA tube plus 6,000 fibroin fibers, or autologous nerves were implanted into 10 mm rat sciatic n...

The repair of peripheral nerve injury has always been a difficult clinical problem. Although variety treatment methods are available in practice, their efficacy is limited. In recent years, the components carried by adipose stem cell exosomes and functions have increasingly discovered. A large number experiments conducted around world shown that adipose-derived positive effect on injury. This a...

End-to-end suture of nerves and autologous nerve grafts are the 'gold standard' for repair and reconstruction of peripheral nerves. However, techniques such as sutureless nerve repair with tissue glues, end-to-side nerve repair and allografts exist as alternatives. Biological and synthetic nerve conduits have had some success in early clinical studies on reconstruction of nerve defects in the h...

introduction: currently, neuroresearchers report that the median nerve shows severity-correlated intracarpal enlargement in idiopathic carpal tunnel syndrome (cts) as a most common peripheral neuropathic disorder. the purpose of this paper was to investigate ultrasonography morphological findings in patients with idiopathic cts and comparing some physical properties such as age, gender, bmi wit...

introduction: according to the high incidence of bell's palsy (ifp) and lack of clinical data regarding different aspects of disease, the present study investigated 121 iranian patients with peripheral facial paralysis referred to the emergency department. methods: in this retrospective study, all patients with peripheral facial paralysis, referred to the emergency department of poursina hospit...