Endometriosis is a common, estrogen-dependent disease, in which endometrial tissue grows the peritoneal cavity. These lesions often express low levels of progesterone receptors (PR), potentially play an important role insufficient response to progestin treatment. Here, we uncover interconnection between downregulated PR expression and epithelial-to-mesenchymal transition (EMT) endometriotic les...

BACKGROUND Endometriosis is known as one of the most common disease in women of reproductive age. Due to important role of vascular endothelial growth factor (VEGF) in neo-vascularization for the implantation of endometrial cell, and also presence of different studies reported VEGF level in the serum and peritoneal fluid (PF) in endometriosis patients, this study was designed to determine the s...

OBJECTIVE Endometriosis is characterized by repeated inflammatory changes and serious adhesions, inducing innate and adaptive immune responses within the abdominal cavity. To assess these immune responses, we evaluated the levels of expression of Toll-like receptors (TLR)-1, -2, -4, -5, and -9; nucleotide-binding oligomerization domains (NOD)-1 and -2; interleukins-1β, -6, -8, -10, and -12; int...

Recent studies of the peritoneal cavity environment in endometriosis demonstrate quantitative and qualitative changes in the cells responsible for cell-mediated immunity. Such changes may have led to disturbances in the surveillance, recognition, and destruction of misplaced endometrial cells and might have, in fact, brought about the disease. The aim of the study was to assess CD95 (Fas) expre...

The aim of the study – to conduct a comparative retrospective analysis medical histories patients with endometriosis associated infertility and tubo-peritoneal factor Materials Methods. A 485 patient’s histories, who applied centre “Yuzko Medical Center” regarding for period 2019–2022 was conducted. main group (I) consists 435 women infertility, endometriosis. control (II) 50 tubal-peritoneal f...

Endometriosis is a gynecologic illness that affects women of reproductive age. The presence endometrial tissue outside the uterine cavity distinguishes it. Pelvic discomfort and infertility plague who are affected. Retrograde menstruation, coelomic metaplasia, induction theory three main ideas have been proposed to explain complex etiology. development also influenced by genetics epigenetics. R...

Endometriosis is defined as the growth of endometrial glandular and stromal components in ectopic locations and affects as many as 10% of all women of reproductive age. Despite its high prevalence, the pathogenesis of endometriosis remains poorly understood. MicroRNAs, small non-coding RNAs that post-transcriptionally regulate gene expression, are mis-expressed in endometriosis but a functional...

BACKGROUND Endometriosis is a complex disease that can result in substantial morbidity, including chronic pain, dysmenorrhea and dyspareunia. There are contradictory reports regarding the connection between acute and chronic stress and magnesium levels in body fluids. SUBJECTS AND METHODS A prospective study included 87 patients undergoing laparoscopy. The study group included 40 women with e...

BACKGROUND Matrix metalloproteinases (MMPs) are a family of endopeptidases which play a role in the degradation and turnover of extracellular matrix proteins. Their action is regulated by specific tissue inhibitors called tissue inhibitors of metalloproteinases (TIMPs). METHODS We measured the concentrations of total and active MMP-9 in peritoneal fluid of infertile women with mild or moderat...