Ischemic preconditioning is a physiologic phenomenon that occurs in the cardiac muscle in which brief episodes of ischemia protect the heart when exposed to a sustained ischemia. Clinical counterparts include potential benefits of preinfarction angina and less ischemia after a second, compared to a first, coronary angioplasty balloon inflation. This article will discuss how preconditioning migh...

Cardiac ischemia-reperfusion injury is evoked by reactive oxygen species (ROS). We previously reported that sulfaphenazole (SPZ) attenuated cardiac ROS levels and ischemia-reperfusion injury in rats. SPZ has distinct two actions: a) elimination of ROS and b) inhibition of cytochrome P450 (CYP) that is responsible for ROS production. The aim of this study is to determine which action contributes...

Interruption of coronary flow during cardiac surgical procedures provides a bloodless flaccid heart and allows precise and rapid correction of complex cardiac defects. However, myocardial damage occurs in direct proportion to the duration of the ischemia. As the induction of cardioplegia simulataneous with the initiation of cardiac ischemia helps to preserve cardiac energy reserves and thus myo...

objective(s) the aim of this study was to investigate the overall effect of cardiac vasoactive factors during coronary occlusion and reperfusion on peripheral vascular tone, using a sequential isolated rabbit heart-ear perfusion model. materials and methods isolated ears were perfused with the effluent of isolated hearts subjected to ischemia (30 min) and reperfusion (180 min, n=6). the compara...

SUMMARY In order to study left ventricular performance and motion under ischemic stress, incremental atrial pacing was performed in 10 patients with angiographically proven coronary artery disease until angina pectoris or segmental S-T depression appeared. Single-plane left ventricular cineangiograms were obtained in both the resting and the transiently ischemic state induced by pacing. Abnorma...

AIM To evaluate the cardioprotective effect of sevoflurane on a beating heart in patients undergoing coronary artery bypass grafting with normal preoperative left ventricular function. METHODS The randomized controlled study included 32 patients induced with sevoflurane and then randomized to receive either 1 minimal alveolar concentration (MAC) end-tidal concentration of sevoflurane (n=16) o...

Abstract Background Imbalances in autophagy are known to have either protective or detrimental effects on cardiac function. Although there significant insights into the early steps of pathway, mechanisms autophagosome-lysosome transport and fusion cardiomyocytes less understood. Fyco1 is highly expressed heart facilitates autophagosomes cardiomyocytes, enhancing global autophagic flux. Purpose ...

OBJECTIVE Peripheral vascular surgery involving limb ischemia/reperfusion is associated with tumor necrosis factor-alpha production and an increased risk of cardiac complications. The objective of this study was to investigate the role of tumor necrosis factor-alpha in myocardial apoptosis and dysfunction following hindlimb ischemia/reperfusion. DESIGN Randomized perspective animal study. S...

Varadarajan, Srinivasan G., Jianzhong An, Enis Novalija, Steven C. Smart, and David F. Stowe. Changes in [Na]i, compartmental [Ca ], and NADH with dysfunction after global ischemia in intact hearts. Am J Physiol Heart Circ Physiol 280: H280–H293, 2001.—We measured the effects of global ischemia and reperfusion on intracellular Na, NADH, cytosolic and mitochondrial (subscript mito) Ca, relaxatio...