نتایج جستجو برای: permeabilization

تعداد نتایج: 2702  

2007
Stefan Grube Uwe Wolfrum Peter Langguth

Membrane destabilizing properties and increased efflux of doxorubicin from liposomes caused by basic butylated methacrylate copolymer (BBMC), better known under its commercial trade name EUDRAGIT E, have been described in the scientific literature. Here, we investigated the effect of BBMC on suspended and filter-grown Caco2 cells with respect to apical-to-basal transport and membrane permeabili...

Journal: :Cold Spring Harbor perspectives in biology 2013
Stephen W G Tait Douglas R Green

Although required for life, paradoxically, mitochondria are often essential for initiating apoptotic cell death. Mitochondria regulate caspase activation and cell death through an event termed mitochondrial outer membrane permeabilization (MOMP); this leads to the release of various mitochondrial intermembrane space proteins that activate caspases, resulting in apoptosis. MOMP is often consider...

2017
Uris Ros Aida Peña-Blanco Kay Hänggi Ulrich Kunzendorf Stefan Krautwald W. Wei-Lynn Wong Ana J. García-Sáez

Necroptosis is a form of regulated necrosis that results in cell death and content release after plasma membrane permeabilization. However, little is known about the molecular events responsible for the disruption of the plasma membrane. Here, we find that early increase in cytosolic calcium in TNF-induced necroptosis is mediated by treatment with a Smac mimetic via the TNF/RIP1/TAK1 survival p...

Journal: :Journal of immunological methods 2007
Laura Papagno Jorge R Almeida Elisa Nemes Brigitte Autran Victor Appay

The rapid progress in flow cytometry means that an increasing number of parameters can be looked at simultaneously, which is highly relevant for the assessment of lymphocyte characteristics, in particular their multifunctional profile. However, procedures using less complex technology need now optimization in order to take into account the new reagents and applications related to polychromatic ...

Journal: :Cold Spring Harbor perspectives in biology 2013
Urška Repnik Maruša Hafner Česen Boris Turk

The endocytic pathway is a system specialized for the uptake of compounds from the cell microenvironment for their degradation. It contains an arsenal of hydrolases, including proteases, which are normally enclosed in membrane-bound organelles, but if released to the cytosol can initiate apoptosis signaling pathways. Endogenous and exogenous compounds have been identified that can mediate desta...

2013
Mireille Laforge Sophie Limou Francis Harper Nicoletta Casartelli Vasco Rodrigues Ricardo Silvestre Houda Haloui Jean-Francois Zagury Anna Senik Jerome Estaquier

Productive HIV infection of CD4(+) T cells leads to a caspase-independent cell death pathway associated with lysosomal membrane permeabilization (LMP) and cathepsin release, resulting in mitochondrial outer membrane permeabilization (MOMP). Herein, we demonstrate that HIV infection induces damage-regulated autophagy modulator (DRAM) expression in a p53-dependent manner. Knocking down the expres...

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