The acquisition of endocrine resistance is a common obstacle in endocrine therapy of patients with oestrogen receptor-α (ERα)-positive breast tumours. We previously demonstrated that the BIG3-PHB2 complex has a crucial role in the modulation of oestrogen/ERα signalling in breast cancer cells. Here we report a cell-permeable peptide inhibitor, called ERAP, that regulates multiple ERα-signalling ...

A permeable cell system has been developed by treatment with digitonin for studying in vitro DNA replication of chromatin. DNA replication of simian virus 40 nucleoprotein complexes (SV40 chromatin) in digitonin-treated permeable cells was analyzed by electrophoresis in agarose-gel. Autoradiography of the agarose-gel revealed that [32P]dCTP was incorporated in SV40 DNA I, II and replicating int...

In this paper a reactive and concurrent control framework for viewpoint control is developed. The viewpoint control task is decomposed into three control objectives namely; obstacle avoidance, visibility and precision. A moving object is tracked in two panoramic sensors using color, and a scalar uncertainty metric of the object position estimate is introduced. Individual control objectives are ...

Learning by observation allows a software agent to learn an expert’s behaviour, by examining the actions the expert performs in response to inputs, without the expert having to explicitly program the agent. Most learning by observation approaches only make use of the current inputs and actions of the expert and ignore any past inputs or actions. This limits the agents to only being able to lear...

Estimation of local second-degree variation should be a natural first step in computerized image analysis, just as it seems to be in human vision. A prevailing obstacle is that the second derivatives entangle the three features signal strength (i.e. magnitude or energy), orientation and shape. To disentangle these features we propose a technique where the orientation of an arbitrary pattern f i...

We consider an obstacle-type problem ∆u = f(x)χΩ in D u = |∇u| = 0 on D \ Ω, where D is a given open set in Rn and Ω is an unknown open subset of D. The problem originates in potential theory, in connection with harmonic continuation of potentials. The qualitative difference between this problem and the classical obstacle problem is that the solutions here are allowed to change sign. Using geom...

We study the homogenization of an obstacle problem in a perforated domain, when the holes are periodically distributed and have random shape and size. The main assumption concerns the capacity of the holes which is assumed to be stationary ergodic.

this article addresses an efficient and novel method for singularity-free path planning and obstacle avoidance of parallel manipulator based on neural networks. a modified 4-5-6-7 interpolating polynomial is used to plan a trajectory for a spherical parallel manipulator. the polynomial function which is smooth and continuous in displacement, velocity, acceleration and jerk is used to find a pat...

Malta Medical Journal Volume 25 Issue 03 2013 Introduction Empty Nose Syndrome (ENS) is a term first introduced by Kern and Moore which is used to describe a rare spectrum of various symptoms suffered by patients who had had previous radical turbinate surgery with a CT scan appearance of the paranasal sinuses after gross tissue loss. The most common symptom is socalled ‘‘paradoxical’’ nasal obs...

This paper presents a novel microcompartmentalized reaction system for cell-free protein synthesis using semi-permeable microcapsules. We used a microfluidic device to encapsulate template DNA and enzymes for cell-free protein synthesis into semi-permeable microcapsules composed of alginate and polyethylene imine (PEI). The template DNA was encapsulated into individual microcapsules at the conc...