8006 Background: Early PET imaging has emerged as a predictor of EFS in HL, but comparisons of early response assessment by PET vs. CT are limited. Children's Oncology Group (COG) study AHOD0031 was designed to evaluate the paradigm of early-response-based treatment intensity. PET and CT scans were obtained after 2 cycles of ABVE-PC, allowing direct comparison of imaging modalities. We examined...

Ultra-high-frequency (UHF) external acoustic stimulation with the UltraQuiet device (UQ) has been reported to provide significant relief of severe disabling-type tinnitus. The nuclear medicine imaging technique of positron emission tomography (PET) was selected as a monitoring system to compare objectively metabolic alterations in brain function before and after UHF/UQ and to correlate the PET ...

Background Neuroinflammation, which receives ever increasing interest in neurodegenerative diseases, comprises a heterogeneous cascade of events that are thought to be related the downstream neurodegeneration. The aim this study was evaluate binding 11C-Deuterium-L-Deprenyl PET (DED) as measure reactive astrocytes patients with different dementia disorders, and assess its association other dise...

Abstract Aim [ 68 Ga]Ga-PSMA-11 PET/CT allows for a superior detection of prostate cancer tissue, especially in the context low tumor burden. Digital bears potential reducing scan time duration/administered tracer activity due to, instance, its higher sensitivity and improved coincidence resolution. It might thereby expand that is currently limited by Ge/ Ga-generator yield. Our aim was to clin...

UNLABELLED Considering PET/MR imaging as a whole-body staging tool, scan time restrictions in a single body area are mandatory for the cost-effective clinical operation of an integrated multimodality scanner setting. It has to be considered that (18)F-FDG already acts as a contrast agent and that under certain circumstances MR contrast may not yield additional clinically relevant information. T...

Computed Tomographic (CT) screening for lung cancer remains controversial, although the National Lung Screening Trial (NLST) found that low dose CT (LDCT) reduced lung cancer mortality by about 20% [1], the high rate of indeterminate and false positive lung nodules was worrying. The diagnostic work-up of CT nodules considers size (diameter or volume), characteristics (density, morphology, homog...

UNLABELLED Integrated PET/MR systems are becoming increasingly popular in clinical and research applications. Quantitative PET reconstruction requires correction for γ-photon attenuations using an attenuation coefficient map (μ map) that is a measure of the electron density. One challenge of PET/MR, in contrast to PET/CT, lies in the accurate computation of μ maps. Unlike CT, MR imaging measure...