Interactions between mood and cognition have drawn much attention in the fields of psychology and neuroscience. Recent neuroimaging studies have examined a neural basis of the mood-cognition interaction that which emphasize the role of the prefrontal cortex (PFC). Although these studies have shown that natural mood variations among participants are correlated with PFC activity during cognitive ...

This study examined the electrophysiological and morphological characteristics of layers V-VI pyramidal prefrontal cortex (PFC) neurons. In vitro intracellular recordings coupled with biocytin injections that preserved some of the PFC efferents to the nucleus accumbens (NAc) were made in brain slices. Four principal pyramidal cell types were identified and classified as regular spiking (RS) (19...

Rostral prefrontal cortex (PFC) is known to be involved in source memory, the ability to recollect contextual information about an event. However it is unclear whether subregions of rostral PFC may be differentially engaged during the recollection of different kinds of source detail. We used event related functional MRI to contrast two forms of source recollection: (1) recollection of whether s...

BACKGROUND Regions undergoing maturation with CB1 receptors may be at increased risk for cannabis-induced alterations. Here, we examine the relationships between cannabis use and prefrontal (PFC) and inferior parietal gyrification and surface area (SA) in youth. METHODS Participants included 33 cannabis users and 35 controls (ages 18-25). Exclusions included co-morbid psychiatric/neurologic d...

The prefrontal cortex (PFC) is critical for decision making, and it becomes dysfunctional in many neuropsychiatric disorders. Studies in schizophrenia patients and relevant animal models suggest loss of PFC inhibitory interneuron function. For instance, rats with a neonatal ventral hippocampal lesion (NVHL) show a deficient modulation of PFC interneurons by dopamine (DA). Whether the PFC become...

Although the prefrontal cortex (PFC) is consistently found to be associated with various working memory processes, the necessity of the PFC for such processes remains unclear. To elucidate PFC contributions to storage and rehearsal/maintenance processes engaged during verbal working memory function, we assessed behavior of patients with lesions to the left or right lateral PFC, and neural activ...

Following unilateral brain injury, patients are often unable to detect a stimulus presented in the contralesional field when another is presented simultaneously ipsilesionally. This phenomenon has been referred to as extinction and has been conceptualized as a deficit in selective attention. Although most commonly observed following damage to posterior parietal areas, extinction has been observ...

Increasing evidence has suggested that the interaction between dopaminergic and glutamatergic systems in prefrontal cortex (PFC) plays an important role in normal mental functions and neuropsychiatric disorders. In this study, we examined the regulation of NMDA-type glutamate receptors by the PFC dopamine D4 receptor (one of the principal targets of antipsychotic drugs). Application of the D4 r...

The hemispheric encoding/retrieval asymmetry (HERA) model is a process-specific description of experimental data provided by a large set of functional neuroimaging studies. According to HERA, left prefrontal cortex (PFC) is more involved than right PFC in episodic memory encoding, whereas right PFC is more involved than left PFC in episodic memory retrieval. Recently it has been claimed that th...

This paper deals with a design problem of an adaptive and performance-driven PID control with an adaptive Neural Network (NN) feedforward control for discrete-time systems with a parallel feedforward compensator (PFC). By adopting PFC design scheme based on FRIT approach, which can design PFC only using an input/output experimental data, a performance-driven adaptive PID control will be propose...