نتایج جستجو برای: pfcrt
تعداد نتایج: 384 فیلتر نتایج به سال:
Imported malaria has been a great challenge for public health in China due to decreased locally transmitted cases and frequent exchange worldwide. Plasmodium falciparum has been mainly responsible for the increasing impact. Currently, artesunate plus amodiaquine, one of the artemisinin combination therapies recommended by the World Health Organization, has been mainly used against uncomplicated...
Malaria is a major global public health problem mainly in the tropics and subtropics. control elimination strategies rely on efficacious antimalarial drugs. At present hurdle faced by malaria programs drug resistance to antimalarials. Molecular surveillance using genetic markers associated with provides valuable tool for detecting tracking as well providing an in-depth understanding of developm...
During 2010-2012, an outbreak of 210 cases of malaria occurred in Tumbes, in the northern coast of Peru, where no Plasmodium falciparum malaria case had been reported since 2006. To identify the source of the parasite causing this outbreak, we conducted a molecular epidemiology investigation. Microsatellite typing showed an identical genotype in all 54 available isolates. This genotype was also...
Due to the widespread prevalence of resistant parasites, chloroquine (CQ) was removed from front-line antimalarial chemotherapy in the 1990s despite its initial promise of disease eradication. Since then, resistance-conferring mutations have been identified in transporters such as the PfCRT, that allow for the efflux of CQ from its primary site of action, the parasite digestive vacuole. Chemose...
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