نتایج جستجو برای: phagocyte disorders
تعداد نتایج: 673312 فیلتر نتایج به سال:
The in vitro oxygen uptake of rainbow trout phagocyte-enriched head kidney leucocyte and head kidney macrophage suspensions was monitored. Stimulation of these cells with zymosan or phorbol myristate acetate induced a twoto 10-fold increase in oxygen uptake, the so-called respiratory burst. This respiratory burst activity was markedly enhanced in the presence of the calcium ionophore A23187 and...
The contribution of CCR6 and phagocyte recruitment to the initiation of T cell responses to a local pathogen is unclear. CD4 T cell activation to an injected soluble antigen occurred rapidly and was completely CCR6-independent. In marked contrast, the tempo of pathogen-specific CD4 T cell activation depended on whether the antigen was secreted or cell-associated. Furthermore, lymph node pathoge...
Exposure of phagocytes to non-spherical particles has provided evidence for multiple actions of the actin system in force generation. For the uptake of long cylindrical particles, a "motile actin clamp" mechanism is proposed. When a phagocyte is engaged with an hour-glass-shaped particle, it exerts contractile activity alternatively at the far end of the particle or at its concave region. Phago...
SUMMARY The ubiquitously expressed cell surface glycoprotein CD47 is expressed by virtually all cells in the host, where it can function to regulate integrin-mediated responses, or constitute an important part of the erythrocyte band 3/Rh multi-protein complex. In addition, CD47 can protect viable cells from being phagocytosed by macrophages or dendritic cells. The latter mechanism is dependent...
Chronic Granulomatous Disease is the most commonly encountered immunodeficiency involving the phagocyte, and is characterized by repeated infections with bacterial and fungal pathogens, as well as the formation of granulomas in tissue. The disease is the result of a disorder of the NADPH oxidase system, culminating in an inability of the phagocyte to generate superoxide, leading to the defectiv...
The phagocyte respiratory burst is crucial for innate immunity. The transfer of electrons to oxygen is mediated by a membrane-bound heterodimer, comprising gp91phox and p22phox subunits. Deficiency of either subunit leads to severe immunodeficiency. We describe Eros (essential for reactive oxygen species), a protein encoded by the previously undefined mouse gene bc017643, and show that it is es...
The accurate assessment of immune competence through ex vivo analysis is paramount to our understanding of those immune mechanisms that lead to protection or susceptibility against a broad range of human pathogens. We have developed a flow cytometry-based, whole blood phagocyte functional assay that utilizes the inflammatory inducer zymosan, coupled to OxyBURST-SE, a fluorescent reporter of pha...
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