Flash chemistry based on high-resolution reaction time control using flow microreactors enables chemical reactions that cannot be done in batch and serves as a powerful tool for laboratory synthesis of organic compounds and for production in chemical and pharmaceutical industries.

INTRODUCTION1, 2 In the last decade, interest in developing a combination of two or more Active Pharmaceutical Ingredients (API) in a single dosage form (bi-layer tablet) has increased in the pharmaceutical industry, promoting patient convenience and compliance. Bi-layer tablets can be a primary option to avoid chemical incompatibilities between APIS by physical separation, and to enable the de...

1Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1/3, 612 42 Brno, Czech Republic 2Callum Consultancy LLC, 571 Berwyn Baptist Road, Devon, PA 19333, USA 3Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale Hall 236-18, 19555 N. 59th Avenue, Glendale, AZ 85308, USA 4Faculty of Health S...

This presentation will give an overview of the current use of nanoparticles as drug carriers and will discuss their future use in drug targeting and drug delivery of active molecules. Today’s progress in cell biology and biotechnology enables scientists to synthesize highly active molecules to target specific intra-cellular receptors. The clinical use of such molecules is often very limited bec...

Every year, there is more and waste on our planet. This leads to soil, water air pollution, which negatively affects people’s health quality of life. Therefore, the task reducing production consumption waste, as well choosing effective directions for their use, becomes urgent. During food products, mainly plant animal origin. The main types generated at processing enterprises have been determin...

linear–dendrite copolymers containing hyper branched poly(citric acid) and linear poly(ethylene glycol) blocks pca–peg–pca are promising nonmaterial to use  in nanomedicine. to investigate their potential application in biological systems (especially for drug carries) oniom2 calculations were applied to study the nature of particular interactions between drug and the polymeric nanoparticles.  b...

Cell-penetrating peptides (CPPs) have been previously shown to be powerful transport vector tools for the intracellular delivery of a large variety of cargoes through the cell membrane. Intracellular delivery of plasmid DNA (pDNA), oligonucleotides, small interfering RNAs (siRNAs), proteins and peptides, contrast agents, drugs, as well as various nanoparticulate pharmaceutical carriers (e.g., l...

Thanks to developments in the field of nanotechnology over the past decades, more and more biosafe nanoscale materials have become available for use as pharmaceutical adjuvants in medical research. Nanomaterials possess unique properties which could be employed to develop drug carriers with longer circulation time, higher loading capacity, better stability in physiological conditions, controlle...

Transdermal administration of drugs has advantages over conventional oral administration or administration using injection equipment. The route of administration reduces the opportunity for drug evacuation before systemic circulation, and enables long-lasting drug administration at a modest body concentration. In addition, the skin is an attractive route for vaccination, because there are many ...

The use of gas-filled microbubbles in perfusion monitoring as intravascular ultrasound contrast agents has recently become more common. Additionally, microbubbles are employed as carriers of pharmaceutical substances or genes. Microbubbles have great potential to improve the delivery of therapeutic materials into cells and to modify vascular permeability, causing increased extravasation of drug...