BACKGROUND Using a large cohort of western Canadian sawmill workers (n = 28,794), the association between psychosocial work conditions and attempted and completed suicide was investigated. METHODS Records of attempted and completed suicide were accessed through a provincial hospital discharge registry to identify cases that were then matched using a nested case control method. Psychosocial wo...

BACKGROUND Access to medicines is an important health policy issue. This paper considers demand structures in a selection of low-income countries from the perspective of public authorities as the evidence base is limited. Analysis of the demand for medicines in low-income countries is critical for effective pharmaceutical policy where regulation is less developed, health systems are cash constr...

Increased demand for treatment of skin wrinkles has led to a proliferation of different pharmaceutical and surgical treatment methods. However there still remains a lack of quantitative, objective, easily utilizable and reproducible wrinkle classification system by which these treatments can be studied and compared. We propose the use of a novel photometric stereo based technique as a potential...

Heparin is an anionic polysaccharide that is widely used as a clinical anticoagulant. This glycosaminoglycan is prepared from animal tissues in metric ton quantities. Animal-sourced heparin is also widely used in the preparation of low molecular weight heparins that are gaining in popularity as a result of their improved pharmacological properties. The recent contamination of pharmaceutical hep...

This paper examines the economic prospects for biotechnology industry, focusing on the U.K. position. We discuss some economic issues relating to the structure of the biotech industry and examine whether these factors can account for the relative success of the biotechnology sector in the U.K. compared to other European countries. We emphasise the importance of the science base, pharmaceutical ...

Diarylmethylamines are of great interest due to their prevalence in pharmaceutical chemistry. As a result, new methods for their synthesis are in demand. Herein, we report a versatile protocol for the synthesis of diarylmethylamine derivatives involving palladium-catalyzed arylation of in situ generated 2-azaallyl anion intermediates. The 2-azaallyl anions are generated by reversible deprotonat...

A number of papers have empirically investigated the rational addiction model proposed by Becker and Murphy (1988) by using data on different harmful drugs, like cigarettes, alcohol, caffeine, opium, cocaine; but also activities independent of a biological or pharmaceutical dependency have been analysed, such as gambling, calorie consumption, news, arts, and cinema. The purpose of this paper is...

Today, a strong research effort is directed towards the development and integration of new materials, especially of polymers and biomolecules which are essential in pharmaceutical, bioengineering, and sensing applications. In fact, patterning of organic and inorganic materials, in particular enabling precise positioning of different materials with nano and micro scale resolution over large area...

Sei Murakami, Dr. Eng. Haruo Suzuki Keisuke Shibuya, Dr. Sc. OVERVIEW: The development of innovative pharmaceuticals with potential for meeting unmet medical needs and vaccines that protect against infectious diseases is very important for ensuring people’s health and welfare. However, biopharmaceuticals and vaccines that make these developments possible are more easily affected by the producti...

This paper investigates how to control an integrated supply chain based on demand-driven principles and sharing of real time information. A set of principles to support a unified supply chain control model is proposed based on theory and previous and ongoing research and illustrated in a case example from the pharmaceutical industry. Essential elements include application of pull-based control ...