Status Final Author(s) Ivan Martinez (AtoS), Miguel Angel Tinte (AtoS) This project is supported by the European Commission under the Information and Communication Technologies (ICT) Theme of the 7th Framework Programme for Research and Technological Development.

Planar cell polarity (PCP) signalling is a well-conserved developmental pathway regulating cellular orientation during development. An evolutionarily conserved pathway readout is not established and, moreover, it is thought that PCP mediated cellular responses are tissue-specific. A key PCP function in vertebrates is to regulate coordinated centriole/cilia positioning, a function that has not b...

These studies tested the hypothesis that a single dose of high-affinity anti-phencyclidine monoclonal antibody (anti-PCP mAb) provides long-term protection against behavioral effects of repeated PCP administration in rats. Rats were treated with saline, nonspecific bovine IgG (NS-IgG), or anti-PCP mAb (1.0 g/kg). The next morning, the rats were challenged with escalating i.v. doses of PCP (0.32...

Just as physics requires a different set of tools to explore phenomena at the quantum scale, chemistry requires a quantum paradigm. At the macroscale, the interaction of light with chemical entities can be observed in processes such as photosynthesis. But the actual interaction between photons and other matter occurs in the realm of quantum chemistry. National Academy of Sciences member and phy...

This study examined the perceived social, behavioral, and health effects of phencyclidine (PCP) use among a sample of 200 users in northern California. The study population, generated through snowball sampling techniques, included heavy chronic, light chronic, and recreational users; the vast majority of subjects were not in treatment facilities. Subjects reported that PCP use-particularly long...