Treatment with phenobarbital of rats which are genetically selected results in a greater than IO-fold increase in nicotinamide-adenine dinucleotide (NAD)-dependent aldehyde dehydrogenase present in the supernatant but not the mitochondrial fraction of liver. This effect represents one of only a few known cases where intrastrain differences in a drug-induced increase in enzyme activity is geneti...

In male BALB/c mice, a combination of individually non-lethal doses of 6-mercaptopurine and endotoxin was significantly lethal. In contrast, mice treated with phenobarbital were resistant to this lethal effect. The high levels of thioinosinic acid in mice that were treated with endotoxin contrasted significantly with the levels in phenobarbital-treated mice. On the other hand, the concentration...

DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a potentially life-threatening syndrome, which reflects a serious hypersensitivity reaction to drugs, presenting by generalized skin rash, fever, eosinophilia, atypical lymphocytosis, and internal organ involvement. Herein a 21-month old male infant with DRESS and Encephalopathy syndrome is presented who complicated after phe...

Introduction: The purpose of this study was to histologically evaluate the influence of phenobarbital on orthodontic tooth movement. Methods: Twenty-two New Zealand rabbits (Oryctolagus cuniculus) were divided into three groups: normal or non-tested (N), control (C), and experimental (E). In Group N (n = 2) no procedure was carried out, except to verify the condition of normality before treatme...

We describe a sensitive, precise high-pressure liquid chromatographic method in which 5-(p-methylphenyl)-5-phenylhydantoin is used as the internal standard for simultaneous determination of diphenylhydantoin, phenobarbital, and primidone in whole blood and plasma. These anticonvulsant drugs are well separated from each other and from normal blood constituents in less than 10 min. The lower limi...

A B S T R A C T Administration of phenobarbital to rats in a dosage schedule previously demonstrated to increase hepatocellular binding of thyroxine results in increased hormonal turnover, due both to increased deiodination and to fecal disposition of thyroxine iodine. The rate of biliary excretion of thyroxine iodine is roughly proportional to the hepatic content of exchangeable thyroxine. The...

pretreatment of adults of iraq strain of afhstephenst with a sub-letlial dose of pcrmethrin resulted in a 65% enliancemenl of tolerance to this insecticide. similarly, pre-exposure of dub-lpr larvae to a sub-lethal dose of pcrmethrin resulted in increased tolerance to pcrmethrin. for the sensitive ind-s strain, the inductive effect was smaller. tiie results of bioassays of resistant and suscept...

objective to determine the changes in thyroid function tests in children who underwent antiepileptic therapy in shahid beheshti hospital, kashan, in 2008. materials & methods this analytical-observational study was carried out in a cohort fashion without an external control group (self controlled) on 45 children with new onset epilepsy who had not been previously treated with antiepileptic medi...