Fibroblast growth factor (FGF)-23 is probably the most important regulator of serum phosphate and calcitriol (1,25(OH)₂D₃) levels. It is secreted by osteocytes and osteoblasts in response to oral phosphate loading or increased serum 1,25(OH)₂D₃ levels. In human chronic kidney disease (CKD), plasma FGF-23 appears to be a sensitive biomarker of abnormal renal phosphate handling, as FGF-23 levels ...

Phosphate clearance by polysulfone (PS) and cuprophane (CU) membranes and the relationship of peridialytic changes in serum phosphate with those of serum-ionized calcium, parathyroid hormone (PTH), and insulin were studied in six stable patients undergoing chronic hemodialysis (HD). Dietary phosphate intake was 25.7 mmol/day, and total dose of elemental calcium was 3.2 g/day. Patients were dial...

Objectives: To assess the Knowledge, Attitude and Practice regarding phosphate binders among ESRD patients on maintenance hemodialysis in South India. And also, to its adverse effects impact gastrointestinal system. Methods: We conducted a cross sectional prospective study at nephroplus vakula dialysis center SVIMS, Tirupati for period of 6 months. A total 226 were included study, who are betwe...

UNLABELLED Background. Retrospective, observational studies link high phosphate with mortality in dialysis patients. This generates research hypotheses but does not establish "cause-and-effect." A large randomised controlled trial (RCT) of about 3000 patients randomised 50 : 50 to lower or higher phosphate ranges is required to answer the key question: does reducing phosphate levels improve cli...

BACKGROUND Previous trials of binders in chronic kidney disease (CKD) stages 3-5 have shown only modest changes in serum phosphate but evaluated morning phosphate. It is unknown whether a circadian pattern of phosphate concentrations exists in CKD and is modifiable by dietary manipulation. OBJECTIVES We determined the circadian pattern of serum phosphate concentrations in CKD and whether it w...

Binders are of prime importance in the agglomeration of iron ore concentrates. In this research, strength and density of briquette produced from the magnetite concentrate of Gol-E-Gohar were investigated using different binders at various applied pressures. The results showed that peridor was the most effective binder relative to bentonite and lime. For all types of binders, the increase in bin...

Dietary intervention, phosphate (P) removal during dialysis and, especially, phosphate binders are current methods for the management of hyperphosphataemia. Ideally, the amount of P absorbed from the diet should equal the amount of P removed during dialysis, and this must occur in the context of an adequate protein intake. We evaluated the relationship between P intake and protein intake in 60 ...