LASER PHOTOSENSITIZATION AND METABOLIC INHIBITION OF TISSUE CULTURE CELLS TREATED WITH QUINACRINE HYDROCHLORIDE M. W . Berns, S . E1-Kadi, R . S . Olson and D. E . Rounds Department of Zoology, University of Michigan Ann Arbor, Michigan and The Pasadena Foundation for Medical Research Pasadena, California (Received 1 June 1970; in final form 27 July 1970) In a preliminary report (1) it was sugg...

Oleic, Laurie, Palmitic, Myristic, and Stearic Acids are fatty acids with hydrocarbon chains ranging in length from 12 to 18 carbons with a terminal carboxyl group. These fatty acids are absorbed, digested, and transported in animals and humans. Little acute toxicity was observed when Oleic, Laurie, Palmitic, Myristic, or Stearic Acid or cosmetic formulations containing these fatty acids were g...

I read with interest the brief communication of Drs. Sharquie and Abdulla.1 It is known that lactic acid is a peeling agent, used to treat dyspigmentation, and its main effect lies in the decreased cohesiveness of epidermal cells leading to the peeling effect. I wonder how it can be used to induce pigmentation. I agree it causes inflammation but not to the extent of stimulating the melanocytes ...

Since the discovery of the green fluorescent green protein (GFP) in 1961 many variants of fluorescent proteins (FP) were detected. The importance was underlined by the Nobel price award in chemistry 2008 for the invention, application, and development of the GFP by Shimomura, Chalfie and Tsien. GFP, first described by Shimomura now is indispensible in the scientific daily life. Since then and a...

Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonne...

Photodynamic therapy (PDT) is a promising treatment in cancer therapy, with a photosensitizer activated by visible light. Aloe-emodin (AE) is a promising photosensitive agent. In this study, the photosensitizing effects and possible mechanisms of AE-PDT in MG63 cells were evaluated. The efficiency of AE-PDT was analyzed by MTT assay. The mode of cell death was investigated by Hoechst 33,342 sta...

Multiwell plates (MWPs) are the workhorses of life sciences. However, biophotonics research with MWPs is limited, in part due to lack equipment suitable for photo-irradiation photoactive molecules a MWP-suitable, high-throughput manner, either commercially or through open-source MWP systems. Here we present “LightBox”, calibrated controllable illumination system broad applications including scr...

in this article, we describe a photosensitizer (ps) whose ability to generate singlet oxygen (1o2) and fluorescence emission has been designed as tumor responsive. more specifically, the ps consists of a silicon phthalocyanine (sipc) core, axially substituted with two subphthalocyanine (subpc) units, covalently linked by a disulfide linker, which is cleavable in the presence of a strong reducin...

The photocytotoxicity characteristics of aluminium phthalocyanine chloride (AIPc), aluminium phthalocyanine disulphonate (AlS2Pc), aluminium phthalocyanine tetrasulphonate (AlS4PC) and haematoporphyrin derivative (HpD) were compared using primary cultures of human meningioma cells. Cells were preincubated with the photosensitising agent for 16 h, then illuminated for 15 min with broad band red ...

A new photo-controlled anticancer drug release system is reported based on the photo-induced electron transfer (PET) between semiconductor quantum dots (QDs) and N-methyl-4-picolinium (NAP) ester 1 under the excitation of visible light.