PURPOSE To report the effect of wavefront-guided photorefractive keratectomy and corneal collagen cross-linking (CXL) on visual problems after Ferrara ring segment placement. MATERIALS AND METHODS A 32-year-old male patient was treated with a Ferrara ring segment for keratoconus. One year later, the ring was removed due to severe glare complaints. After 6 months, wavefront-guided photorefract...

In isolated rabbit corneas that had undergone lamellar keratectomy or myopic keratomileusis, the stimulation of chloride transport by 10(-5) M epinephrine was completely inhibited at 1 week following surgery. At 28 days following surgery, both groups responded to 10(-7) M epinephrine. The response to 10(-5) M amphotericin B was normal both at 1 week and at 28 days following surgery. We conclude...

PURPOSE To evaluate the efficacy of unilateral photorefractive keratectomy to correct anisometropia induced by retinal detachment surgery. METHODS Photorefractive keratectomy was performed in 10 eyes of 10 patients with anisometropia induced by previous retinal detachment surgery. The Aesculap Meditec MEL 60 excimer laser was used. RESULTS Preoperative mean spherical equivalent refraction w...

BACKGROUND We report a patient with Salzmann's nodular degeneration in whom the disease occurred without a history of keratitis and recurred twice after keratectomy. CASE A unilateral case of symptomatic Salzmann's nodular degeneration developed after cataract surgery in a 75-year-old woman. OBSERVATIONS We performed superficial keratectomy and amniotic membrane transplantation two times, b...

We engineered phototherapeutic sub-12 nm-sized polymeric micelles to treat malignant brain tumours (MBTs). The engineered nanoparticles in MBT cells enhanced the photocytotoxic efficiency more than 2.5-fold compared with parental and PEGylated photosensitisers (PSs). Increased subcellular co-localisation of PSs in mitochondria was observed.

Enormous interest in porphyrin and its derivatives is due to the essential role these compounds play in living systems and to numerous possible applications, e.g., in medicine, as laser dyes, catalytic and photocatalytic systems. Constitutional isomers of porphyrin: porphycenes, corrphycenes, isoporphycenes proved to be excellent sensitizers for singlet oxygen generation, a feature that makes t...

BACKGROUND The purpose of this study was to compare differences in visual outcomes, higher-order aberrations, contrast sensitivity, and dry eye in patients undergoing photorefractive keratectomy using wavefront-guided VISX CustomVue™ and wavefront-optimized WaveLight(®) Allegretto platforms. METHODS In this randomized, prospective, single-masked, fellow-eye study, photorefractive keratectomy ...

BACKGROUND We conducted a clinical trial to evaluate the efficacy and safety of excimer laser photorefractive keratectomy (PRK) and photoastigmatic refractive keratectomy (PARK) using the Nidek EC-5000 excimer laser. METHODS A total of 67 eyes from 47 patients whose average age was 35 years were enrolled in the study. The mean spherical equivalent of the manifest refraction before surgery was...