Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the damage and activates the checkpoint is not yet understood. To address this issue for alkylation damage, we have reconstituted the checkpoint respon...

This paper presents a review of creep deformation and rupture mechanism of P91 alloy for the development of its creep damage constitutive equations under lower stress level. Creep damage is one of the serious problems for the high temperature industries and computational approach (such as continuum damage mechanics) has been developed and used, complementary to the experimental approach, to ass...

Weak stresses (including weak oxidative stress, cytostatic agents, heat shock, hypoxia, calorie restriction) may extend lifespan. Known as hormesis, this is the most controversial notion in gerontology. For one, it is believed that aging is caused by accumulation of molecular damage. If so, hormetic stresses (by causing damage) must shorten lifespan. To solve the paradox, it was suggested that,...

Recent studies of political behavior suggest that voting decisions can be influenced substantially by "first-impression" social attributions based on physical appearance. Separate lines of research have implicated the orbitofrontal cortex (OFC) in the judgment of social traits on the one hand and economic decision-making on the other, making this region a plausible candidate for linking social ...

An evaluation of the risk to an exposed element from a hazardous event requires a consideration of the element’s vulnerability, which expresses its propensity to suffer damage. This concept allows the assessed level of hazard to be translated to an estimated level of risk and is often used to evaluate the risk from earthquakes and cyclones. However, for other natural perils, such as mass moveme...

The objective of this study was to explore the relationship between oxidative molecular damage and the aging process by determining whether such damage is associated with the rate of aging, using the adult housefly as the experimental organism. Because the somatic tissues in the housefly consist of long-lived postmitotic cells, it provides an excellent model system for studying cumulative age-r...

Local damage models are known to produce pathological mesh dependence in finite element simulations. The solution is to either use a regularization technique or to adopt a non-local damage model. Viscoplasticity is one technique which can regularize the mesh dependence of local damage model by incorporating a physical phenomenon in the constitutive model i.e. rate effects. A detailed numerical ...

Exfoliation of SiC by hydrogen implantation and subsequent annealing forms the basis for a thi n-fiim separation process ~vhichqwhen combined with hydrophilic wafer bonding. can be exploited to produce siIicon-carbide-cm-insulator, SiCOI. Sic thin films produced by this process exhibit unacceptably high resistivity because defects generated by the implant neutralize electrical carriers. Separat...