Niemann-Pick disease type C (NPC) is characterized by substantial intracellular accumulation of unesterified cholesterol. The accumulation of unesterified cholesterol in NPC fibroblasts cultured with low density lipoprotein (LDL) appears to result from the inability of LDL to stimulate cholesterol esterification in addition to impaired LDL-mediated downregulation of LDL receptor activity and ce...

OBJECTIVE To identify poorly compliant glaucoma patients, using the Eye-Drop Satisfaction Questionnaire (EDSQ). METHODS This was an observational cross-sectional study with compliance data collected by an electronic monitoring device. Patients with primary open-angle glaucoma or ocular hypertension completed the EDSQ, a six-dimension self-reported questionnaire addressing "treatment concern",...

Hydrogen is the mainstream future energy source because of its high density and environmentally-friendly properties. In this study, Fe-Co2P/NPC materials were prepared by wet chemical synthesis method, in which Fe-Co2P nanowires wrapped N, P co-doped carbon layers (NPC) under aging phosphorylation strategies. When Fe-Co2P/NPC/NF was subjected to hydrogen evolution reaction (HER) oxygen (OER), o...

This article reviews all related research and reports on nasopharyngeal cancer (NPC) histopathological classifications worldwide. Despite continuous advance of Chinese and international NPC histopathological classification research, it was difficult to unify previous with current China classifications, and the China with World Health Organization (WHO) classifications. For example, non-keratini...

An understanding of how the nuclear pore complex (NPC) mediates nucleocytoplasmic exchange requires a comprehensive inventory of the molecular components of the NPC and a knowledge of how each component contributes to the overall structure of this large molecular translocation machine. Therefore, we have taken a comprehensive approach to classify all components of the yeast NPC (nucleoporins). ...

An understanding of how the nuclear pore complex (NPC) mediates nucleocytoplasmic exchange requires a comprehensive inventory of the molecular components of the NPC and a knowledge of how each component contributes to the overall structure of this large molecular translocation machine. Therefore, we have taken a comprehensive approach to classify all components of the yeast NPC (nucleoporins). ...

The efficacy of neoadjuvant chemotherapy and adjuvant chemotherapy on stage IIb nasopharyngeal carcinoma(NPC) remains unclear. Conventional two-dimensional radiotherapy combined with concurrent chemotherapy can improve the overall survival, progression-free survival, recurrence-free survival, and distant metastasis-free survival of patients with stage IIb NPC. Intensity-modulated radiotherapy w...

BACKGROUND Nasopharyngeal carcinoma (NPC) is known for its high metastatic potential and locoregional recurrence, although the molecular alterations that are driving NPC metastasis remain unclear at this time. This study aimed to examine the expression of fibulin-5 in NPC, correlate the results with clinicopathological variables and survival, and to investigate the role of fibulin-5 in human NP...

Abstract Objectives The objectives of this scoping review were to (a) explore how pharmacists perceive their professional roles and identities (b) describe factors impacting which or embody in different pharmacy practice settings. Methods A using a deductive approach was undertaken for study. Systematic searches conducted five databases: Ovid MEDLINE, EMBASE, PsycINFO, EBSCO Cumulative Index Nu...