نتایج جستجو برای: pi 23755 2
تعداد نتایج: 2554750 فیلتر نتایج به سال:
Voltage-sensing phosphatases (VSPs) consist of a voltage-sensor domain and a cytoplasmic region with remarkable sequence similarity to phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a tumor suppressor phosphatase. VSPs dephosphorylate the 5' position of the inositol ring of both phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P(3)] and phosphatidylinositol 4,5-bisphosphate [...
The two conjectures are, of course, equivalent. If 2n — 2 = pi+p2, then 2n = pi+p2+2 and 2n + l = pi+p2+3Conversely, if 2n=pi -\-p2-\-pz one of the primes must be 2 and 2n — 2 = pi+p2. An impressive collection of numerical evidence indicating the truth of the conjectures has accumulated in the years since Goldbach's letter was written, but is it not known to this day whether the conjectures are...
G. Bonvicini, D. Cinabro, M. Dubrovin, A. Lincoln, D. M. Asner, K. W. Edwards, P. Naik, R. A. Briere, T. Ferguson, G. Tatishvili, H. Vogel, M. E. Watkins, J. L. Rosner, N. E. Adam, J. P. Alexander, D. G. Cassel, J. E. Duboscq, R. Ehrlich, L. Fields, R. S. Galik, L. Gibbons, R. Gray, S. W. Gray, D. L. Hartill, B. K. Heltsley, D. Hertz, C. D. Jones, J. Kandaswamy, D. L. Kreinick, V. E. Kuznetsov,...
Purinergic control of apical plasma membrane PI(4,5)P2 levels sets ENaC activity in principal cells.
Activity of the epithelial sodium channel (ENaC) is limiting for Na(+) reabsorption at the distal nephron. Phosphoinositides, such as phosphatidylinositol 4,5-biphosphate [PI(4,5)P(2)] modulate the activity of this channel. Activation of purinergic receptors triggers multiple events, including activation of PKC and PLC, with the latter depleting plasma membrane PI(4,5)P(2). Here, we investigate...
The membrane receptors for the gibbon ape leukemia retrovirus and the amphotropic murine retrovirus serve normal cellular functions as sodium-dependent phosphate transporters (Pit-1 and Pit-2, respectively). Our earlier studies established that activation of protein kinase C (PKC) by treatment of cells with phorbol 12-myristate 13-acetate (PMA) enhanced sodium-dependent phosphate (Na/Pi) uptake...
In actin-based cell motility, phosphate (Pi) release after ATP hydrolysis is an essential biochemical process, but the actual pathway of Pi separation from actin is not well understood. We report a series of molecular dynamics simulations that induce the dissociation of Pi from actin. After cleavage from ATP, the singly protonated phosphate (HPO4(2-)) rotates about the ADP-associated Ca2+ ion, ...
Synthesis and redox behavior of biferrocenyl-functionalized ruthenium(II) terpyridine gold clusters.
Spectroscopic and electrochemical characterizations of ferrocene- and biferrocene-functionalized terpyridine octanethiolate monolayer-protected clusters were investigated and reported. The electrochemical measurements of Ru2+ coordinated with 4'-ferrocenyl-2,2':6',2' '-terpyridine and 4'-biferrocenyl-2,2':6',2' '-terpyridine complexes were dominated by the Ru2+/Ru3+ redox couple (E(1/2) at appr...
We study random generation in the symmetric group when cycle type restrictions are imposed. Given $\pi, \pi' \in S_n$, we prove that $\pi$ and a conjugate of $\pi'$ likely to generate at least $A_n$ provided only have not too many fixed points $2$-cycles. As an application, investigate following question: For which positive integers $m$ should expect two elements order $A_n$? Among other things...
The synthesis, spectroscopic characterization, and X-ray crystal structure of the sodium salt of a new sulfonated water-soluble ligand, sodium 2-(2-pyridin-2-yl-ethylamino)-benzenesulfonate (L) are described. Compound L crystallizes in the centrosymmetric space group Pbcn, orthorhombic, a=31.930(13) A, b=7.153(3) A,c=14.193(6) A, alpha=90.00, beta=90.00, gamma=90.00, V=3220(2) A(3), Z=9. pi-pi ...
TRPV3 is a thermosensitive channel that is robustly expressed in skin keratinocytes and activated by innocuous thermal heating, membrane depolarization, and chemical agonists such as 2-aminoethyoxy diphenylborinate, carvacrol, and camphor. TRPV3 modulates sensory thermotransduction, hair growth, and susceptibility to dermatitis in rodents, but the molecular mechanisms responsible for controllin...
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