نتایج جستجو برای: pic mcc simulation
تعداد نتایج: 565933 فیلتر نتایج به سال:
Particle-In-Cell (PIC) schemes are ones of the most broadly used numerical methods in kinetic simulation plasmas. The contribution present paper is dedicated to introduction novel parallelization strategies specific shared memory architectures tailored for implementing sparse grid reconstructions. These operate different parallelisms genuine Sparse-PIC obtain speed-up exceeding 100 on 128 cores...
Molecular characterization of the non-biotin-containing subunit of 3-methylcrotonyl-CoA carboxylase.
The biotin enzyme, 3-methylcrotonyl-CoA carboxylase (MCCase) (3-methylcrotonyl-CoA:carbon-dioxide ligase (ADP-forming), EC 6.4.1. 4), catalyzes a pivotal reaction required for both leucine catabolism and isoprenoid metabolism. MCCase is a heteromeric enzyme composed of biotin-containing (MCC-A) and non-biotin-containing (MCC-B) subunits. Although the sequence of the MCC-A subunit was previously...
Mucociliary clearance (MCC) is the key defense mechanism in the upper airways, as the removal of debris-laden mucus in the sinuses completely depends on MCC. So far, how the nasal MCC is regulated remains unknown. Recently, mice deficient in genes encoding the components of MCC apparatus have been generated, which will allow investigators to conduct more in-depth nasal MCC studies. However, the...
Merkel cell carcinoma (MCC) is a relatively uncommon but highly lethal form of skin cancer. A majority of MCC tumors carry DNA sequences derived from a newly identified virus called Merkel cell polyomavirus (MCV or MCPyV), a candidate etiologic agent underlying the development of MCC. To further investigate the role of MCV infection in the development of MCC, we developed a reporter vector-base...
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma that only rarely regresses spontaneously. Since little is known about the immunological mechanisms involved in the spontaneous regression of MCC, we describe a case of MCC with spontaneous regression and employed immunohistochemical staining for cytotoxic and immunosuppressive molecules to investigate possible mechanisms invo...
To support the design and analysis of x-ray radiographic facilities and experiments at Los Alamos, we have developed an integrated chain model, which is a set of linked physics simulation codes to generate self-consistent synthetic radiographs of experiments [1]. The expectation-maximization (EM) algorithm [2] has recently been used to great advantage to link particlein-cell (PIC) methods, whic...
Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer with profound but poorly understood resistance to chemotherapy, which poses a significant barrier to clinical MCC treatment. Here we show that ATP-binding cassette member B5 (ABCB5) confers resistance to standard-of-care MCC chemotherapeutic agents and provide proof-of-principle that ABCB5 blockade can inhibit human M...
Particle-in-cell (PIC) methods allow the study of plasma behavior by computing the trajectories of finite-size particles under the action of external and self-consistent electric and magnetic fields defined in a grid of points. In this work, the Finite Element Method (FEM) is used in order to obtain the self-consistent fields. An electrostatic PIC-FEM computational code for simulation of one-di...
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