Background: Risk factors affecting cutaneous melanoma metastasis and prognosis have been actively studied. Previously, we had found that amelanotic mild pigmentation of acral was associated with first distant metastasis, whereas heavy lymph node metastasis. Objective: We aimed to confirm lymphatic proliferation invasion according degree in melanoma, by immunohistochemical stains cell culture. M...

STATEMENT OF THE PROBLEM Melanin pigmentation of the gingiva is a crucial esthetic problem. A variety of methods have been used for gingival depigmentation. PURPOSE The purpose of this study was to compare the results of two treatment modalities: scalpel technique and cryotherapy with liquid nitrogen in treatment of gingival pigmentation. MATERIALS AND METHOD Twenty patients with chief comp...

NCKX5 is an ion exchanger expressed mostly in pigment cells; however, the functional role for this protein in melanogenesis is not clear. A variant allele of SLC24A5, the gene encoding NCKX5, has been shown to correlate with lighter skin pigmentation in humans, indicating a key role for SLC24A5 in determining human skin colour. SLC24A5 expression has been found to be elevated in melanoma. Knock...

The purpose of this study was to determine the effects of skin pigmentation regarding Near Infrared Spectroscopy (NIRS) tissue oxygen saturation values (StO2). The study examined NIRS values in individuals with varying skin pigmentation on the anterior compartment of the lower leg and volar forearm to determine if correlation exists among three NIRS devices, the EQUANOX, Casmed, and INVOS. Skin...

A 38- year-old man in good general health and normal intellectualfunctioning referred to the dermatologic clinic with numerouspruritic reticulate pigmentations on his neck, chest and upperback since 10 years ago. We noticed similar lesions on his axillae,groin and infra mammary area with no family background.