BACKGROUND Guidelines for the management of hypertension recommend the use of drugs with different mechanisms of action in antihypertensive regimens that include single-pill fixed-dose combinations of medications. There is some controversy regarding which single-pill fixed-dose combinations of angiotensin II type 1 receptor blockers (ARBs) and calcium channel blockers (CCBs) are effective at re...

We consider the problem of resequencing a pre-arranged set of jobs on a moving assembly line with the objective of minimizing changeover costs. A changeover cost is incurred whenever two consecutive jobs do not share the same feature. Features are assigned from a set of job-specific feasible features. Re-sequencing is limited by the availability of offline buffers. The problem is motivated by a...

Following injury to a peripheral nerve, patients may complain of pain over the distribution of the same contralateral nerve, a phenomenon referred to as contralateral pain or mirror pain (MP). Symptoms of MP usually begin after the neuropathic pain from the original nerve injury has become chronic. Chronic neuropathic pain can lead to sensitization and spread of pain. Because the diagnosis of M...

The chronic conditions growth is determined by an increase of cases of adaptive system imbalance following a recent disease. One of its most significant causes is decrease of crisis importance (a stage of disease) as a moderator of a qualitative changeover of an adaptive system. The contemporary treatment methods increase efficiency of pre-crises adaptive responses, but simultaneously they equa...

In this paper, we propose a novel algorithm for synthesizing the pipeline structures with variable data initiation intervals (DIIs). Compared to previous researches where the pipeline synthesis is confined to those with fixed DIIs, the proposed algorithm tries to optimize the pipeline latency by fully utilizing hardware resources to which abstract operations in high-level design descriptions ar...