4-(4-Methyl-piperazin-1-ylmethyl)-N-[6-methyl-5-(4-pyridin-3-yl-pyrimidin-2-ylamino)-pyridin-3-yl]-3-trifluoromethyl-benzamide (flumatinib, HH-GV678), an antineoplastic tyrosine kinase inhibitor, is currently in Phase I clinical trials in China for the treatment of chronic myelogenous leukemia (CML). The purpose of this study was to identify the metabolites of flumatinib in CML patients, with t...

In this study, a derivative method is applied for the determination of dye concentration in fabrics dyed with tricomponent dye mixtures. The reflectance of spectra of the samples were recorded between 400 and 700 nm. Initially, the obtained (K/S) spectra were divided by the spectrum of a standard sample dyed with two of the components in the ternary mixture and the derivative spectra were calcu...

Positive allosteric modulation of metabotropic glutamate subtype 5 (mGlu5) receptor has emerged as a potential new therapeutic strategy for the treatment schizophrenia and cognitive impairments. However, positive modulator (PAM) agonist activity been associated with adverse side effects, neurotoxicity also observed pure PAMs. The structural pharmacological basis versus mGlu5</su...

two sensitive spectrophotometric methods are presented for the assay of repaglinide in bulkdrug and in formulations using methyl orange, as reagents. oxidant by reacting with a fixedamount of either methyl orange and measuring the absorbance at 485.2 nm (method-i) andmeasuring the absorbance at 618.9 nm (method-ii). developed method is based on the formationof extractable colored complex of dru...

In this paper, we establish the existence and uniqueness result of the linear Schrodinger equation with Marchaud fractional derivative in Colombeau generalized algebra. The purpose of introducing Marchaud fractional derivative is regularizing it in Colombeau sense.