Near-infrared photoimmunotherapy (NIR-PIT), a promising cancer therapy utilizing an antibody-photoabsorber conjugate (APC) and NIR light, which induces rapid necrotic cell death only in APC-bound cells. Effective NIR-PIT in mouse models has been achieved using superficial light illumination (SLI) with light emitting diodes (LEDs) or lasers, but in the clinical setting, fiber optic diffusers hav...

Decision-making depends on the ability to extract predictive information from the environment to guide future actions. Outcome-specific Pavlovian-instrumental transfer (PIT) provides an animal model of this process in which a stimulus predicting a particular outcome biases choice toward actions earning that outcome. Recent evidence suggests that cellular adaptations of δ-opioid receptors (DORs)...

Introduction: Central pit craters are an unusual class of impact crater seen most commonly on the icy Galilean satellites and Mars. They are characterized by terraced rims and flattened floors with a pit at or near the center (see Fig 1). Their association with ice-rich surfaces has led most hypotheses for the origins of central pits to rely on the volatility or weakness of water ice [e.g. 1, 2...

Early Neolithic Settlement burials in Central Europe have long been treated as an irregularity and thus sparked discussions about perceptions of social deviancy. In recent years, the highly increased number documented settlement suggests that they constituted integral part a more complex system burial practices, which precludes dichotomous division into ‘regular’ ‘irregular’ burials. Based on c...

Similar to the mixed-integer programming library (MIPLIB), we present a library of publicly available test problem instances for three classical types of open pit mining problems: the ultimate pit limit problem and two variants of open pit production scheduling problems. The ultimate pit limit problem determines a set of notional three-dimensional blocks containing ore and/or waste material to ...

The ecohydrological controls on soil erosion and landscape evolution are difficult to quantify and poorly understood. In many parts of the world, cyclone-induced tree throw is a major source of disturbance. Tree throw may increase sediment transport by exposing a mound of fresh soil as well as providing a pit which may act as a knickpoint triggering gully erosion. Alternatively, while tree thro...

A gene encoding the Tilapia mossambica (Oreochromis mossambicus) growth hormone (tiGH) was isolated and sequenced. The gene spans 5.6 kb, including 3.7 kb of 5' and 0.2 kb of 3' flanking sequences and a 1.7-kb transcription unit comprised of six exons and five introns. The gene and the 5' flanking region contain several potential binding sites for Pit-1, a key transcription activator of mammali...

This paper presents the results of a mixed-methods study examining adaptation strategies that property owners in low-income, rapidly urbanizing areas in Malawi adopt to address the limitations of pit latrines, the most common method of disposing human excreta. A particular challenge is lack of space for constructing new latrines as population density increases: traditional practice has been to ...

Elasmobranchs have hundreds of tiny sensory organs, called pit organs, scattered over the skin surface. The pit organs were noted in many early studies of the lateral line, but their exact nature has long remained a mystery. Although pit organs were known to be innervated by the lateral line nerves, and light micrographs suggested that they were free neuromasts, speculation that they may be ext...