Learning processes mediating conditioning and extinction of contextual fear require activation of several key signaling pathways in the hippocampus. Principal hippocampal CA1 neurons respond to fear conditioning by a coordinated activation of multiple protein kinases and immediate early genes, such as cFos, enabling rapid and lasting consolidation of contextual fear memory. The extracellular si...

The effects of intra-accumbens sulpiride on conditioned place preference and locomotion produced by i.v. cocaine were investigated. Every other day during conditioning, rats received infusions of sulpiride (0-0.4 microgram) into the nucleus accumbens (NAc) or caudate-putamen. Fifteen min later, they were placed into a distinct compartment and injected with saline or cocaine (4.2 mg/kg, i.v.). O...

The present study investigated the effect of acamprosate on ethanol (EtOH)-induced place preference in mice with EtOH physical dependence. The expression of EtOH (2 g/kg, intraperitoneally)-induced place preference in mice without EtOH treatment before the experiment was dose-dependently suppressed by acamprosate. The levels of protein kinase A (PKA) and phospho-cAMP response element binding pr...

Tobacco products are widely abused in humans, and it is assumed that nicotine is the key substrate in these products that produces addiction. Based on this assumption, several pre-clinical studies have utilized animal models to measure various aspects of nicotine addiction. Most of this work has focused on behavioral measures of nicotine and how other variables contribute to these effects. Here...

Three experiments tested whether events taking place before a rat has access to a target taste, sucrose, can proactively interfere with the acquisition of a sucrose aversion when sucrose is followed by a lithium chloride injection. Using a serial overshadowing procedure with various delays before lithium injection, proactive interference by a taste (Experiments 1 and 3) and by a novel context (...

Ground-source heat pump (GSHP) systems can achieve a higher coefficient of performance than conventional airsource heat pump (ASHP) systems because the ground, which functions as the heat source or sink, is at a higher temperature in winter and lower in summer than the air temperature (Kavanaugh 1992; Kavanaugh et al 1997). In addition, there will likely be some mitigation against the effects o...

In 3 experiments, rats were used to investigate the conditions that influence the transfer of a conditioned emotional response from 1 context to another. The subjects experienced training in 2 contexts on each day. In Experiment 1, subjects received a single conditioning trial with a different target stimulus in each of the 2 contexts. Conditioned responding was found to be more vigorous when t...

statement of problem: considering the cost and amount of time and also the quantity of tooth loss in the process of cavity preparation, repair of the restoration instead of its replacement would be much more efficient. purpose: the aim of this study was to determine the effect of different methods of surface conditioning on the shear bond strength of repaired compomers. materials and methods: s...

Repeated hypercapnic exercise augmented the ventilatory response to subsequent trials of exercise alone in running goats and in humans performing arm exercise, suggesting a form of associative conditioning or 'long-term modulation' had taken place. These studies did not include 'control' single stimulus conditioning paradigms. This study demonstrated that ten repeated trials of familiar leg bic...

The conditioning theory of fear-acquisition is outlined and the supporting evidence and arguments presented. It is argued that the theory lacks comprehensiveness and is also inadequate in other respects. Six arguments against acceptance of the theory are advanced. People fail to acquire fears in what are theoretically fear-evoking situations (e.g. air raids). It is difficult to produce conditio...