background: eicosapentaenoic acid (epa) is the principal ω-3 fatty acids in marine oils. fasting blood sugar (fbs), hba1c and some of the plasma lipids and lipoproteins has been negatively related to the intake of ω-3 fatty acids and ascorbic acid, in some studies. therefore, the purpose of this study was to assess the effects of epa and/or vitamin c on glycemic indices, blood pressure, and pla...

BackgroundProgressive supranuclear palsy is a neurodegenerative disorder associated with tau protein aggregation. Tilavonemab (ABBV-8E12) monoclonal antibody that binds to the N-terminus of human tau. We assessed safety and efficacy tilavonemab for treatment progressive palsy.MethodsWe did phase 2, multicentre, randomised, placebo-controlled, double-blind study at 66 hospitals clinics in Austra...

This study assessed the efficacy, tolerability and safety of vortioxetine versus placebo in adults with recurrent major depressive disorder. This double-blind, randomized, placebo-controlled study included 608 patients [Montgomery-Åsberg Depression Rating Scale (MADRS) total score ≥ 26 and Clinical Global Impression - Severity score ≥ 4]. Patients were randomly assigned (1 : 1 : 1 : 1) to vorti...

5-Hydroxytryptamine (5-HT; serotonin) has been implicated in the perception of exercise-induced fatigue. Sumatriptan is a selective 5-HT(1B/D) receptor agonist which does not cross the blood-brain barrier. The aim of the present study was to determine the effect of sumatriptan on exercise capacity. Ten healthy male subjects (mean age 28.4+/-10.8 years) performed a maximal treadmill exercise tes...

BACKGROUND This double-blind, placebo-controlled study was conducted to assess the efficacy of the nonabsorbed oral antibiotic rifaximin to prevent shigellosis in volunteers challenged with Shigella flexneri. METHODS Volunteers were randomized to receive either prophylactic rifaximin (200 mg 3 times daily for 3 days; n = 15) or placebo (n = 10) on days 0, 1, and 2. On day 1, volunteers were c...

Background Dapagliflozin reduces the risk of kidney failure and heart in patients with chronic disease. We aimed to investigate effects dapagliflozin on kidney, cardiovascular, mortality outcomes according presence or absence type 2 diabetes underlying cause disease, reported as diabetic nephropathy, glomerulonephritides, ischaemic hypertensive disease other unknown cause. Methods DAPA-CKD was ...

Background: The administration of opioids before induction of general anesthesia can be considered as a problem in cesarean section. The aim of this study was to compare the effects of intravenous Fentanyl as a premedication before induction of general anesthesia versus placebo on maternal hemodynamic parameters and on the first and fifth minutes Apgar score in the neonates in elective cesarean...