According to Process Analytical Technology perspective, drug product quality should be ensured by manufacturing process design. Initial step of the process analysis is investigation of critical process parameters (CPPs). It is generally accepted to type the CPPs based on project team knowledge and experience [5]. This paper describes the use of Design of Experiments tool for selection of the CP...

Background A glycolipopeptide biosurfactant produced by Pseudomonas aeruginosa strain IKW1 reduced the surface tension of fermentation broth from 71.31 to 24.62 dynes/cm at a critical micelle concentration of 20.80 mg/L. The compound proved suitable for applications in emulsion stabilization in food, as well as in cosmetic and pharmaceutical formulations. Method In the present study, Plackett...

Given the lack of accurate parameter values in discrete element simulation sweet potato seedling mechanized recovery, a direct measurement and virtual calibration method was used to study Discrete Element Method (DEM) parameters broken stems leaves. The intrinsic parameters, collision recovery coefficient static friction seedlings were acquired by physical experiments. Different combinations de...

Abstract The goal of this study is to identify the optimum conditions for ochratoxin A (OTA) biodegradation by supernatant Agaricus campestris strain. Plackett–Burman and Box–Behnken methods were used determine OTA degradation under various incubation conditions. method was planned through 16 varied experiments with 15 variants. three most potent variants, sucrose, yeast extract wheat bran, sel...

We introduce a novel methodology for determining the difficulty of modeling a given data set. The method utilizes formulation of modeling as an optimization problem instance that consists of an objective function and a set of constraints. The properties of the data set that could affect the quality of optimization are categorized. In large optimization problems with multiple properties that con...

The mutant of Pediococcus pentosaceus (SPAm) produced earlier by UV-mutagenesis exhibiting higher dextransucrase activity as compared to wild-type was used. The generated mutant SPAm gave 12.2 mg/ml, a 20% higher dextran than wild-type. Response surface methodology was carried out for further enhancement of dextran production. To enhance dextran production by the mutant SPAm, Plackett-Burman De...