BACKGROUND Lower vitamin B(6) concentrations are reported to confer an increased and independent risk for cardiovascular disease (CVD). The mechanism underlying this relationship, however, remains to be defined. Other diseases, such as rheumatoid arthritis, are associated with reduced vitamin B(6) levels. Despite a clear distinction in pathophysiology, inflammatory reaction may be the major lin...

Background: Familial hypobetalipoproteinaemia (FHBL) is an autosomal co-dominant hereditary disorder of lipoprotein metabolism characterised by decreased low density lipoprotein (LDL) cholesterol and apolipoprotein B (APOB) plasma levels. High levels of plasma APOB and LDL cholesterol are strong predictors for risk of cardiovascular disease (CVD), while individuals with low APOB and LDL cholest...

Eggs contain high quality protein, vitamins, minerals and antioxidants, yet regular consumption is still met with uncertainty. Therefore, the purpose of this study was to compare the effects of consuming two eggs per day or a heart-healthy oatmeal breakfast on biomarkers of cardiovascular disease (CVD) risk and satiety measures in a young, healthy population. Fifty subjects participated in a ra...

Excessive procoagulant activity in the alveolar space may play a relevant role in the pathogenesis of pulmonary fibrosis. Hypercoagulability results from the disruption of the balance between the procoagulant and anticoagulant factors. The aim of this study was to assess the levels of molecular markers of the anticoagulant protein C (PC) pathway in the bronchoalveolar lavage fluid (BALF) and pl...

Lipoprotein(a) (Lp(a)), first discovered by Kare Berg in 1963, is an independent risk factor for the development of atherosclerotic cardiovascular disease (CVD) [1]. The structure of Lp(a) is similar to that of low density lipopro-tein; both complexes contain a lipid core surrounded by apolipoprotein B (apoB), but in Lp(a), a unique apolipo-protein, apolipoprotein A (apo(a)), is covalently boun...

Hyperhomocysteinemia (Hhcy) has been associated with pathological and stressful conditions and is a risk factor for cardiovascular disease (CVD). The aim of this study was to evaluate the correlation between plasma homocysteine (hcy) and lipid peroxidation in patient with CVD. This study was carried out on 40 patients with CVD as well as 15 healthy volunteers of comparable age and gender as con...

BACKGROUND Familial hypobetalipoproteinaemia (FHBL) is an autosomal co-dominant hereditary disorder of lipoprotein metabolism characterised by decreased low density lipoprotein (LDL) cholesterol and apolipoprotein B (APOB) plasma levels. High levels of plasma APOB and LDL cholesterol are strong predictors for risk of cardiovascular disease (CVD), while individuals with low APOB and LDL choleste...

Aging is characterized by systemic deterioration of biomolecules and increased incidence of oxidative stress. In addition, occurrence of dyslipidemia in elderly significantly contributes the development of cardiovascular disease. It is conceivable that association of dyslipidemia with oxidative stress enhances the future the risk of cardiovascular disease (CVD) in older population. The aim is t...

OBJECTIVE To examine a panel of 28 biomarkers for prediction of cardiovascular disease (CVD) and non-CVD mortality in a population-based cohort of men. METHODS Starting in 1979, middle-aged men in Caerphilly underwent detailed medical examination. Subsequently 2171 men were re-examined during 1989-1993, and fasting blood samples obtained from 1911 men (88%). Fibrinogen, viscosity and white ce...

The intrinsic properties of vertically aligned graphene (VG), such as a high ratio exposed active edge sites compared to inert basal sites, non-stacking morphology and large surface-to-volume make it applicable numerous advanced technologies sensors, flexible electronics fuel cells. Plasma-enhanced chemical vapour deposition has emerged promising technique synthesise at lower temperatures than ...