Abstract Background Cardiovascular heart disease is the leading cause of mortality worldwide, with rupture or thrombosis an atherosclerotic plaque being main reason behind acute coronary syndrome. It has already been established that morphology plaques determine their stability. A lipid rich lesion a thin fibrous cap more prone to compared solid lesions. In PROSPECTII study we used Near infrare...

Preparations of platelet concentrates (PCs) that are stored under blood bank conditions and used for transfusion purposes, appear to be enriched in platelet derived-microparticles (PMPs) with high coagulant activity that may change platelet efficacy and safety issues. High shear stress could cause shedding of PMPs from the platelet plasma membrane, platelet aggregation, and activation of the co...

Abstract Abstract Background: Availability and affordability of medicines are crucial to achieving success in prevention programs, particularly in developing countries. Objective: The aim of this study was to determine the availability and affordability of cardiovascular medicines for secondary prevention in Tehran province of Iran. Methods: A cross-sectional survey was conducted in Tehran pro...

Cancer is a major public health burden in both developed and developing countries. It is the second largest common disease spread world-wide. Traditional medicines or herbal formulations can serve as the source of potential new drugs, so that initial research focuses on the active constituent of the plants. The development of novel plant derived natural products and their analogs for anticancer...

Glyceraldehyde (GLA) was determined in glucose degradation and glycation. GLA was detected as a decahydroacridine-1,8-dione derivative on reversed phase HPLC using cyclohexane-1,3-dione derivatizing reagent. The glucose-derived GLA level was higher than the glycation-derived GLA level, because GLA was converted to intermediates and advanced glycation end products (AGE) in glycation. GLA was als...

The study aimed to synthesise qualitative studies of lay experiences of medicine taking. Most studies focused on the experience of those not taking their medicine as prescribed, with few considering those who reject their medicines or accept them uncritically. Most were concerned with medicines for chronic illnesses. The synthesis revealed widespread caution about taking medicines and highlight...

India is a varietal emporium of the medicinal and aromatic plants (MAPs) and we have well-established local healthcare tradition still relevant in indigenous healthcare system 1,2 . As per World Health Organisation (WHO) estimates, almost 80% of the population of developing countries relies on traditional medicines, mostly plant drugs, for their primary health care needs 3-5 . In developed coun...

Medicinal plants and preparations derived from plants in the Caucasus and North America regions have for a long time been used for the treatment and prevention of virtually all human afflictions. Even today, countries and people of these areas continue to test and use plants as medicine. Indeed, the study and application of medicinal plants and plant extracts has formed the basis for treatment ...

This study aims to discuss approaches to assessing the value of medicines. Economic evaluation assesses value by means of the incremental cost-effectiveness ratio (ICER). Health is maximized by selecting medicines with increasing ICERs until the budget is exhausted. The budget size determines the value of the threshold ICER and vice versa. Alternatively, the threshold value can be inferred from...