LDH-C4 is a lactate dehydrogenase that catalyzes the interconversion of pyruvate with lactate. In mammals the, Ldh-c gene was originally thought to be expressed only in testis and spermatozoa. Plateau pika (Ochotona curzoniae), belonging to the genus Ochotona of the Ochotonidea family, is a hypoxia tolerant mammal living at 3000-5000 m above sea levelon the Qinghai-Tibet Plateau. We found that ...

The surface air temperature change over the Tibetan Plateau is determined based on historical observations from 1980 to 2013. In contrast to the cooling trend in the rest of China, and the global warming hiatus post-1990s, an accelerated warming trend has appeared over the Tibetan Plateau during 1998-2013 (0.25 °C decade(-1)), compared with that during 1980-1997 (0.21 °C decade(-1)). Further re...

BACKGROUND Nasal nitric oxide is present in high concentrations in the upper airway relative to the lower respiratory tract. OBJECTIVE To explore the rate of nitric oxide accumulation in the nonventilated nasal cavity. METHODS In 9 healthy subjects previously trained to close the soft palate, steady-state plateau nitric oxide levels were recorded while air was aspirated through the nasal ai...

Changes in myocardial electrical impedance (MEI) and physiological end points have been correlated during acute ischemia. However, the importance of MEI's early time course is not clear. This study evaluates such significance, by comparing the temporal behavior of MEI during acute total occlusion of the left anterior descending coronary artery in anesthetized humans, dogs, and pigs. Here, inter...

The plateau pika (Ochotona curzoniae) is a species of sprint-running alpine animals in the Qinghai-Tibet Plateau, which is a harsh highland hypoxic environment. Ldh-c is expressed in the testis, sperm and somatic tissues of plateau pika. To reveal the role and physiological mechanisms of sperm-specific lactate dehydrogenase (LDH-C4), in plateau pika to adapt to hypoxic environment, an adenovira...

Right atria from dog hearts were immersed in Tyrode's solution with the endocardial surface of the anterior wall exposed. Glass microelectrodes were used to impale fibers in diSerent anatomical areas of this preparation. Electrical characteristics of atrial plateau fibers located along the caval border of the crista terminalis were compared with those of regular atrial fibers from other sites. ...

Newly dated Tertiary strata in the Bolivian central Andean plateau and synthesis of the Tertiary record in the adjacent Subandean fold-thrust belt constrain the age of deformation in both regions. Age of deformation within the plateau is determined by dated crosscutting relations associated with a regionally extensive high-level surface known as the San Juan del Oro surface. New Ar-Ar dates on ...

The Tibetan Plateau is an important water source in Asia. As the "Third Pole" of the Earth, the Tibetan Plateau has significant dynamic and thermal effects on East Asian climate patterns, the Asian monsoon process and atmospheric circulation in the Northern Hemisphere. However, little systematic knowledge is available regarding the changing climate system of the Tibetan Plateau and the mechanis...

[1] Current models of long-term river incision into bedrock suggest that the local rate of differential rock uplift should exert a primary control on the gradient of channel longitudinal profiles. However, discrimination of this effect from the influence of variations in substrate erodibility, sediment flux, precipitation, and transient changes in profile shape has proved difficult in practice....

Dispersal is an important aspect in organism's life history which could influence the rate and outcome of evolution of organism. Plateau pika is the keystone species in community of grasslands in Tibetan Plateau. In this study, we combine genetic and field data to character the population genetic pattern and dispersal dynamics in plateau pika (Ochotona curzoniae). Totally, 1,352 individual samp...