UNLABELLED BACKGROUND Postprandial hyperlipidemia and hyperglycemia have been related to cardiovascular events. Among different underlying mechanisms platelet activation seems to be responsible too. No comparable data between various tests in normo- vs. hyperlipidemics before and at different time intervals are available after a fat meal. We aimed to compare 9 of them within the same patient...

BACKGROUND AND OBJECTIVES Inhibition of soluble fibrinogen binding to activated platelets represents the target of pharmacologic approach with antagonists of the glycoprotein IIb/IIIa (GPIIb/IIIa) complex. In this study we assessed the effects of abciximab, a recombinant chimeric Fab fraction of the antibody against GPIIb/IIIa, on several markers of platelet activation. DESIGN AND METHODS The...

Abnormal expression of thymic stromal lymphopoietin (TSLP) and its receptor (TSLPR) was found in patients with acute coronary syndrome. Ticagrelor, an oral platelet ADP P2Y12 receptor antagonist, is widely used in these patients. The aim of this study was to verify whether different doses of ticagrelor regulated plaque progression and platelet activity by modulating TSLP/TSLPR. Seventy-five Apo...

[Purpose] Osteoporosis is an inflammatory disease, and platelets play a critical role in bone remodeling. Mean platelet volume has been shown to be influenced by inflammation. Our aim was to evaluate the relationship between mean platelet volume and bone mineral density in postmenopausal women. [Subjects and Methods] The records of female patients who had been referred to a tertiary hospital fo...

AIM To evaluate the levels of nitrite (NO(-)(2)) and nitrate (NO(-)(3)) ions and the incorporation of [(3)H]arachidonic acid (AA) into phospholipids of platelet membranes from coronary artery disease (CAD) patients with and without diabetes (NIDDM). SUBJECTS AND METHODS Eighteen CAD patients (group A), 18 CAD patients with NIDDM (group B), and 20 healthy controls (group C) without dyslipidemi...

CONTEXT Reliable platelet counting is crucial for indicating prophylactic platelet transfusion in thrombocytopenic patients. OBJECTIVE To evaluate the precision and accuracy of platelet counting for thrombocytopenic patients, using four different automated counters in comparison with the Brecher & Cronkite reference method recommended by the International Committee for Standardization in Hema...

OBJECTIVE To evaluate the effect of maternal low dose aspirin ingestion in platelet function of newborn. DESIGN Prospective randomized placebo controlled study. METHODS 25 neonates born to mothers receiving low dose aspirin and 25 matched neonates with no maternal exposure to aspirin were studied. 2 ml of EDTA and 4.5 ml of citrate blood was collected from umbilical vein using double clampe...

background: immune thrombocytopenic purpura (itp) is a disease characterized by decrease of the peripheral blood platelet count. the disease presents in acute and chronic forms. because of the importance and high prevalence of itp, it was decided to study the therapeutic response of patients with itp. material and methods: a cross-sectional study was conducted at ghaem hospital, mashhad, iran. ...

platelet adherence surrounding leucocytes in a rosette formation or platelet satellitism is a rare phenomenon. this finding has been observed almost exclusively in ethylenediaminetetraacetic acid treated blood at room temperature. the mechanism underlying this phenomenon is not fully understood. in many reports of platelet satellitism platelets clump to polymorphonuclear neutrophils in healthy ...