نتایج جستجو برای: platelets

تعداد نتایج: 44753  

Journal: :The Journal of clinical investigation 1997
J E Freedman J Loscalzo M R Barnard C Alpert J F Keaney A D Michelson

Vessel injury and thrombus formation are the cause of most ischemic coronary syndromes and, in this setting, activated platelets stimulate platelet recruitment to the growing thrombus. Recently, a constitutive nitric oxide synthase (NOS) has been identified in human platelets. To further define the capacity of platelets to produce nitric oxide (NO), as well as to study the role of this NO in pl...

Journal: :Blood 1990
M Cattaneo M T Canciani A Lecchi R L Kinlough-Rathbone M A Packham P M Mannucci J F Mustard

Normal human platelets aggregated by thrombin undergo the release reaction and are not readily deaggregated by the combination of inhibitors hirudin, chymotrypsin, and prostaglandin E1 (PGE1). In contrast, thrombin-induced aggregates of platelets from patients with delta-storage pool deficiency (delta-SPD), which lack releasable nucleotides, are readily deaggregated by the same combination of i...

Journal: :Blood 1986
M E Rick D M Krizek

Factor VIII coagulant protein (VIII:C) functions as a critical cofactor with factor IXa, calcium ions, and phospholipid during the activation of factor X. In the course of this reaction, the activity of VIII:C is first increased and then is destroyed by one or more serine proteases that are part of the coagulation sequence. In this study, we have investigated the influence of platelets on the i...

2014
Eric Boilard Guillaume Paré Matthieu Rousseau Nathalie Cloutier Isabelle Dubuc Tania Lévesque Pierre Borgeat Louis Flamand

• In influenza-immune subjects, H1N1 influenza virus–containing immune complexes can activate platelets through FcgRIIA. • H1N1 can also activate platelets through thrombin, independently of FcgRIIA, pointing to a role of coagulation in influenza infection. Platelets play crucial functions in hemostasis and the prevention of bleeding. During H1N1 influenza A virus infection, platelets display a...

Journal: :Blood 1982
J G Kelton C Hamid S Aker M A Blajchman

To investigate whether platelet ABO antigens are intrinsic to platelets or adsorbed from plasma. the amount of A-antigen on washed platelets was determined and related to the Lewis and secretor phenotypes, as these genes control the amount A, B. or H antigen present in plasma. The A-antigen on platelets was quantitated using a platelet-erythrocyte mixed agglutination assay in 28 A1 individuals ...

Journal: :Circulation 2004
P Pignatelli V Sanguigni L Lenti D Ferro A Finocchi P Rossi F Violi

BACKGROUND CD40 ligand (CD40L) expression on platelets is mediated by agonists, but the underlying mechanism is still unclear. METHODS AND RESULTS CD40L expression was measured in platelets from healthy subjects both with and without the addition of antioxidants or a phospholipase A2 (PLA2) inhibitor and in platelets from 2 patients with an inherited deficiency of gp91phox. Immunoprecipitatio...

Journal: :Clinical chemistry 1979
K Kasperek G V Iyengar J Kiem H Borberg L E Feinendegen

The elements Ag, Au, Cd, Co, Cr, Cs, Mo, Rb, Sb, and Se were determined in platelets from seven normal donors. The results, in ng/g wet weight, for plasma-free platelets follow: "Pure" platelets: Ag = 29 +/- (18), au = 0.22 +/- (0.22), Cd = 6.2 +/- 3.4, Cs = 54.8 +/- 19.2, Cr = 6.1 +/- 2.5, Co = 7.5 +/- (5.0), Mo = 3.4 +/- 1.3, Rb = 10400 +/- 3000, Sb = 18 +/- (26), and Se = 782 +/- 127. "Impur...

Journal: :Blood 1974
J P Crowley A Rene C R Valeri

About 60% of the platelets freeze proaddition or removal of the cryoprotective served in 6% dimethylsulfoxide retained agent. Platelets that retained the disc the discoid shape characteristic of fresh shape had a well-preserved ultrastructure, platelets. The remainder wore sphered. but sphered platelets showed extensive Platelet sphering occurred during freezing ultrastructural changes. and tha...

2015
Antoine Dewitte Annabelle Tanga Julien Villeneuve Sébastien Lepreux Alexandre Ouattara Alexis Desmoulière Christian Combe Jean Ripoche

The role of platelets extends beyond hemostasis. The pivotal role of platelets in inflammation has shed new light on the natural history of conditions associated with acute or chronic inflammation. Beyond the preservation of vascular integrity, platelets are essential to tissue homeostasis and platelet-derived products are already used in the clinics. Unanticipated was the role of platelets in ...

Journal: :The Journal of clinical investigation 1978
T J Kunicki M M Johnson R H Aster

The platelet membrane receptor for quinidine- and quinine-dependent antibodies was studied in three patients with the Bernard-Soulier syndrome (BSS) and in normal subjects with immunologic techniques based on the release of 51Cr from labeled platelets. The receptor could not be detected on BSS platelets but was present on platelets from each of 180 normal subjects. BSS platelets reacted normall...

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