Incomplete DNA methylation reprogramming in cloned embryos leads to poor cloning efficiency. Epigenetic modification agents can improve genomic methylation reprogramming and the development of cloned embryos, however, the effect of epigenetic modification agents on gene-specific methylation reprogramming remains poorly studied. Here, we investigated DNA methylation reprogramming of pluripotency...

Neural stem cells are widely studied for their therapeutic potential and for the insight they reveal into the mechanisms of brain development. The latest advances in neural stem cell research are the topic of this issue's Neurobiology Select. These findings include a simple protocol for reprogramming human neural stem cells to pluripotency and a report demonstrating that transplanted neural ste...