Here, we produce poly(lactide-co-glycolide) (PLGA) based microparticles with varying morphologies, and temperature responsive properties utilizing a Pluronic F127/dextran aqueous two-phase system (ATPS) assisted self-assembly. The PLGA polymer, when emulsified in Pluronic F127/dextran ATPS, forms unique microparticle structures due to ATPS guided-self assembly. Depending on the PLGA concentrati...

UNLABELLED We have developed a methodology for calibrating (68)Ge radioactivity content in a commercially available calibration source for activity calibrators in a way that is traceable to the national standard. Additionally, the source was cross-calibrated for equivalent (18)F content by direct comparison with the national standard for (18)F in the same geometry. METHODS Sources containing ...

PURPOSE Patients with succinate dehydrogenase subunit B(SDHB) mutation-related pheochromocytoma/paraganglioma (PHEO/PGL) are at a higher risk for metastatic disease than other hereditary PHEOs/PGLs. Current therapeutic approaches are limited, but the best outcomes are based on the early and proper detection of as many lesions as possible. Because PHEOs/PGLs overexpress somatostatin receptor 2 (...

The knowledge of the structure function relationship of the allergen is essential to design allergenic variants with reduced IgE binding capacity but intact T cell reactivity. Asp f 2 is a major allergen from the fungus Aspergillus fumigatus and >90% of A. fumigatus-sensitized individuals displayed IgE binding to Asp f 2. In the present study, we evaluated the involvement of C-terminal cysteine...

Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local injection of heparin before a spinal cord injury reduces cell proliferation and astrogliogenesis associated with...

Onion intake might reduce the risk of colorectal cancer, according to epidemiology. However, Femia showed in 2003 that diets with a 20% onion intake increase carcinogenesis in rats. We speculated this dose was too high. Prevention of initiation was thus tested in 60 rats given a 5% dried onion diet or AIN76 diet, and initiated 12 days later with azoxymethane (AOM, 1x20 mg/kg i.p.), 2-amino-3-me...

Our previous studies have demonstrated that surfaceactive copolymers of Pluronic® surfactants and tertiary amino polycations such as poly (2-dimethylaminoethyl methacrylate) (PDMA) possess an enhanced DNA transfection efficiency compared to PDMA homopolymers. In order to understand the mechanism of such action, we conducted model studies of the interaction of polymer with phospholipid vesicles ...

Abstract: This study aimed to evaluate DOX∙HCl loaded P(DLLA-CO:60:40) nanoformulations with a copolymer of F127 as potential drug delivery system for cancer. DOX ∙ HCl was encapsulated in Poly DL-lactic acid co castor oil 60:40, P(DLLACO: 60:40) polymer the copolymer/stabilizer Pluronic® F127. The mean diameter cylindrical rod shape nanoformulation particles 248±2.4-260±3.2 nm an acceptable po...