Primary open-angle glaucoma (POAG) is the major type of glaucoma. To discover genetic markers associated with POAG, we examined a total of 1,575 Japanese subjects in a genome-wide association study (stage 1) and a subsequent study (stage 2). Both studies were carried out at a single institution. In the stage 1 association study, we compared SNPs between 418 POAG patients and 300 control subject...

Background/Aim. Impaired vision resulting from glaucoma can have deleterious effects on both physical and mental health. This study aims at examining the adverse impacts of primary open angle (POAG), closure (PACG) pseudoexfoliation (PEG) quality life (QOL). Methods. research, designed as a cross-sectional study, included 102 patients treated for POAG, PACG, or PEG. The were divided into three ...

The purpose of this paper was to estimate arteriovenous passage (AVP) times, taking into account the non-uniform distribution of arrival times over the vessel diameter, and assessment of respective differences between 15 normal controls (N), 30 primary open-angle glaucoma (POAG) and 30 normal-pressure glaucoma (NPG) patients. Arrival times in retinal vessels were assessed from digitized scannin...

PURPOSE To evaluate the possible correlation between the visual field defects in patients with primary open-angle glaucoma (POAG) and the expression and enzymatic activity of nitric oxide synthase (NOS) isoenzymes and nitrotyrosine in trabecular meshwork (TM) samples. METHODS TM specimens were collected from 146 patients with POAG by using standard filtration surgery. Visual field defects wer...

Primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) are leading causes of irreversible blindness. Several loci have been mapped using genome-wide association studies. Until very recently, there was no recognized overlap in the genetic contribution to AMD and POAG. At genome-wide significance level, only ABCA1 harbors associations to both diseases. Here, we investigated...

PURPOSE To determine the distribution of WDR36 sequence variants in a cohort of patients with primary open-angle glaucoma (POAG) in the United States. METHODS All of the 23 coding exons and flanking introns of the WDR36 gene were sequenced in 118 probands from families with at least two members affected by POAG, 6 probands from juvenile-onset POAG families, and 108 control individuals. RESU...

PURPOSE Alterations of the plasmin system have been suggested to participate in the multifactorial pathogenesis of primary open-angle glaucoma (POAG). The main physiological inhibitor of the plasmin system is plasminogen activator inhibitor-1 (PAI-1), which leads to decreased degradation of extracellular material. Interestingly, elevated PAI-1 levels in the aqueous humor of patients with POAG h...

Hyperhomocysteinemia induced by the C677T genetic variant in MTHFR (methylenetetrahydrofolate reductase) has been implicated in neuronal cell death of retinal ganglion cells (RGC), which is a characteristic feature of glaucoma. However, association of MTHFR C677T with glaucoma has been controversial because of inconsistent results across association studies. Association between MTHFR C677T and ...

purpose : there are controversial reports regarding the long-term intraocular pressure (iop) lowering effect of non-penetrating glaucoma surgery (npgs). the reported complete success rates from studies in different populations around the world are 13% to 77%. this prospective study was aimed to evaluate the iop lowering effect of deep sclerectomy with mitomycin c (dsmmc) in a group of iranian p...

Received for publication November’ 2010 .................................. Purpose: To compare intraocular pressure (IOP) control and post operative complications after trabeculectomy with Mitomycin-C (MMC) in patients with primary open angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). Material and Methods: Sixty patients of both genders with age range of 40 to 70 years, fulfilli...