provided the original work is properly cited. CC Patients, especially pediatric patients, with a recent history of an upper respiratory tract infection (URI) are at a significantly increased risk for the development of intraoperative airway complications due to airway hyperreactivity. For these patients, the incidence for bronchospasm can be 10 times the incidence for those patients who did not...

Eukaryotes typically have three multi-subunit enzymes that decode the nuclear genome into RNA: DNA-dependent RNA polymerases I, II and III (Pol I, II and III). Remarkably, higher plants have five multi-subunit nuclear RNA polymerases: the ubiquitous Pol I, II and III, which are essential for viability; plus two non-essential polymerases, Pol IVa and Pol IVb, which specialize in small RNA-mediat...

Background: The thymidine kinase (TK) and DNA polymerase (pol) genes of herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) are important targets for genotypic determination of HSV resistance to antiviral drugs. The knowledge of gene polymorphism is an absolute requirement for the correct interpretation of genotypic findings. Methods: In this study, the natural polymorphism of TK and DNA pol...

D NA mismatch repair (MMR) is an important postreplicative repair mechanism that removes DNA polymerization errors and is responsible for increasing the fidelity of genome replication by orders of magnitude. Defects in MMR lead to the most common form of hereditary colon cancer and a variety of sporadic cancers (1–3). One of the main features of MMR is its ability to distinguish old and new DNA...