A 10-year-old girl with a combination of paralytic disease, resembling poliomyelitis, and asthma is described. The girl developed neurological symptoms 5 days after a severe attack of asthma. No aetiology to the flaccid paralysis could be demonstrated although Coxsackie B5 virus was isolated from a stool. A similar poliomyelitis-like illness associated with asthma has previously been reported i...

In some parts of the world poliomyelitis is still endemic and there are thousands of young people with joint contractures (Fig. 1). These most commonly occur at the knee, and the aim of treatment must be a straight knee with a useful range of painless flexion so that a hinged caliper can be worn. This paper reports experience in correcting flexion contractures of the knee following poliomyeliti...

1. Experiments are reported on the use of poliomyelitis virus neutralized by specific antiserum as an agent to induce active immunity against the experimental disease in monkeys. 2. The results indicate that protection can be conferred upon a certain number of the treated animals. 3. The neutralized material gave rise in no instance to symptoms of disease in the treated monkeys. 4. Active polio...

When, in 1956, inactivated poliomyelitis (Salk) vaccine became available for routine immunization in England and Wales the Ministry of Health set up a scheme of poliomyelitis surveillance. The objects were to provide a means of rapid detection pf possible outbreaks of vaccine-induced poliomyelitis, such as occurred in the United States owing to the presence of incompletely inactivated virus in ...

Laboratory diagnosis of poliomyelitis is an important part of the WHO initiative for global eradication of poliomyelitis. During the last year, new methods have been developed for the detection of poliovirus in clinical specimens, for intratypic differentiation, for the analysis of poliovirus neurovirulence, and for the detection of poliovirus antibodies. Progress in laboratory techniques for d...

www.thelancet.com Vol 383 May 17, 2014 1697 10 WHO. IHR Emergency Committee concerning Middle East respiratory syndrome coronavirus (MERS-CoV). July 9, 2013. http://www.who.int/ihr/ ihr_ec_2013/en/ (accessed May 6, 2014). 11 Independent Monitoring Board of the Global Polio Eradication Initiative. Sixth Report. London: Independent Monitoring Board, November, 2012. 12 WHO. International travel an...

Global incidence of poliomyelitis has reduced by more than 99% since the Global Polio Eradication Initiative was launched in 1988 [1]. In par with the global trend, Sri Lanka has achieved great success with no reported cases since 1993, but still is not declared as a country which has eradicated polio due to prevalence of polioyomyelitis in neighbouring countries [2]. Countries which have eradi...

The African Region of the World Health Organization includes a diverse membership of 48 countries and territories that has made substantial progress toward controlling poliomyelitis. The coverage with three doses of oral poliovirus vaccine among 1-year-old children reached 58% in 1995, a substantial increase from 49% in 1993, and the incidence of poliomyelitis decreased from 5126 cases in 1980 ...

1. A viral agent, Powers, causing myocarditis, adipositis, pancreatitis, hepatitis, and encephalomyelitis but not myositis in suckling mice 1 to 2 days old has been isolated from the stool of a patient in whom the clinical diagnosis was "non-paralytic poliomyelitis." 2. Serological evidence linking the virus to the clinical disease observed was clear only in the case of "non-paralytic poliomyel...

Because circulation of wild poliovirus in the region has been interrupted, the only known sources of wild poliovirus remaining are within the region’s laboratories. These laboratories may store specimens from known poliomyelitis cases or store other materials that are potentially infected with wild poliovirus (Box 1). Therefore, the task of poliomyelitis eradication will not be complete until a...