The purpose of this study was to develop a novel lipid-polymer hybrid drug carrier comprised of folate (FA) modified lipid-shell and polymer-core nanoparticles (FLPNPs) for sustained, controlled, and targeted delivery of paclitaxel (PTX). The core-shell NPs consist of 1) a poly(ε-caprolactone) hydrophobic core based on self-assembly of poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolact...

BACKGROUND Curcumin (CUR) has been linked with antioxidant, anti-inflammatory, antimicrobial, anti amyloid, and antitumor effects, but its application is limited because of its low aqueous solubility and poor oral bioavailability. METHODS To improve its bioavailability and water solubility, we synthesized two series of poly (ε-Caprolactone)-poly (ethylene glycol)-poly (ε-Caprolactone) tribloc...

Abstract Burn wound infections cause serious problems for public health. More than 180,000 patients die from burns every year worldwide. In addition, the difficulty of healing wounds and caused by affects mental health patients. Therefore, it is very important to develop a dressing that can promote repair exhibits good antibacterial effects. Here, we used oxidized konjac glucomannan (OKGM), γ-p...

We construct pseudorandom generators with improved seed length for several classes of tests. First we consider the class of read-once polynomials over GF(2) in m variables. For error ε we obtain seed length Õ(log(m/ε)) log(1/ε), where Õ hides lower-order terms. This is optimal up to the factor Õ(log(1/ε)). The previous best seed length was polylogarithmic in m and 1/ε. Second we consider produc...